Literature DB >> 17294937

Lack of detectable variation at Borrelia burgdorferi vlsE locus in ticks.

Leanna K Nosbisch1, Aravinda M de Silva.   

Abstract

VlsE is a surface exposed lipoprotein of the Lyme disease spirochete, Borrelia burgdorferi. Spirochetes are able to generate many antigenic variants of VlsE by DNA recombination at the vlsE locus. Novel VlsE antigenic variants are readily observed in mice infected with B. burgdorferi. We followed a clonal population of spirochetes through a tick transmission cycle and report that unlike in vertebrates, the vlsE locus is stable in ticks.

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Year:  2007        PMID： 17294937     DOI： 10.1603/0022-2585(2007)44[168:lodvab]2.0.co;2

Source DB:  PubMed          Journal:  J Med Entomol        ISSN： 0022-2585            Impact factor:   2.278


  6 in total

Review 1.  vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity.

Authors:  Steven J Norris
Journal:  Microbiol Spectr       Date:  2014-12

Review 2.  Genetics of Borrelia burgdorferi.

Authors:  Dustin Brisson; Dan Drecktrah; Christian H Eggers; D Scott Samuels
Journal:  Annu Rev Genet       Date:  2012-09-04       Impact factor: 16.830

3.  Central role of the Holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi.

Authors:  Tao Lin; Lihui Gao; Diane G Edmondson; Mary B Jacobs; Mario T Philipp; Steven J Norris
Journal:  PLoS Pathog       Date:  2009-12-04       Impact factor: 6.823

Review 4.  Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles.

Authors:  Jean I Tsao
Journal:  Vet Res       Date:  2009-04-16       Impact factor: 3.683

5.  A tightly regulated surface protein of Borrelia burgdorferi is not essential to the mouse-tick infectious cycle.

Authors:  Philip E Stewart; Aaron Bestor; Jonah N Cullen; Patricia A Rosa
Journal:  Infect Immun       Date:  2008-03-10       Impact factor: 3.441

6.  Inactivation of genes for antigenic variation in the relapsing fever spirochete Borrelia hermsii reduces infectivity in mice and transmission by ticks.

Authors:  Sandra J Raffel; James M Battisti; Robert J Fischer; Tom G Schwan
Journal:  PLoS Pathog       Date:  2014-04-03       Impact factor: 6.823
  6 in total

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