Literature DB >> 17294834

Effects of cervical-lymphatic blockade on brain edema and infarction volume in cerebral ischemic rats.

Jinchao Si1, Lianbi Chen, Zuoli Xia.   

Abstract

To observe the effects of cervical-lymphatic blockade (CLB) on brain edema and infarction volume of ischemic (MCAO) rat, we examined changes in cerebral water content, Ca2+ and glutamate concentrations, cerebral infarction volume and mRNA expression levels of N-methyl-D-aspartame receptor 1 (NMDA receptor 1) in the ischemic (left) hemisphere. The present results demonstrated that all the above indices in rats with middle cerebral artery occlusion plus cervical lymphatic blockade (MCAO+CLB) were markedly higher than those with only middle cerebral artery occlusion (MCAO) at different time points. These results indicated [corrected] that CLB can aggravate cerebral ischemia by increasing brain edema and infarction volume.

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Year:  2006        PMID： 17294834

Source DB:  PubMed          Journal:  Chin J Physiol        ISSN： 0304-4920            Impact factor:   1.764


  8 in total

1.  Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury.

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Journal:  Brain Behav Immun Health       Date:  2022-05-04

2.  Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers.

Authors:  Olivia M Turk; Ryan C Woodall; Margarita Gutova; Christine E Brown; Russell C Rockne; Jennifer M Munson
Journal:  Drug Deliv Transl Res       Date:  2021-10-30       Impact factor: 5.671

Review 3.  New Brain Lymphatic Vessels Drain Old Concepts.

Authors:  Lasse Dissing-Olesen; Soyon Hong; Beth Stevens
Journal:  EBioMedicine       Date:  2015-08-14       Impact factor: 8.143

4.  A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

Authors:  Aleksanteri Aspelund; Salli Antila; Steven T Proulx; Tine Veronica Karlsen; Sinem Karaman; Michael Detmar; Helge Wiig; Kari Alitalo
Journal:  J Exp Med       Date:  2015-06-15       Impact factor: 14.307

Review 5.  Blood⁻Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne's Thread in Labyrinths of Hypotheses.

Authors:  Oxana Semyachkina-Glushkovskaya; Dmitry Postnov; Jürgen Kurths
Journal:  Int J Mol Sci       Date:  2018-11-30       Impact factor: 5.923

Review 6.  Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective.

Authors:  Korri S Hershenhouse; Orr Shauly; Daniel J Gould; Ketan M Patel
Journal:  Neurosci Insights       Date:  2019-12-31

7.  Extracellular Vesicle-Derived microRNA-410 From Mesenchymal Stem Cells Protects Against Neonatal Hypoxia-Ischemia Brain Damage Through an HDAC1-Dependent EGR2/Bcl2 Axis.

Authors:  Jun Han; Si Yang; Xiaosheng Hao; Bo Zhang; Hongbo Zhang; Cuijuan Xin; Yunpeng Hao
Journal:  Front Cell Dev Biol       Date:  2021-01-11

Review 8.  Established, New and Emerging Concepts in Brain Vascular Development.

Authors:  Ankan Gupta; Kevin R Rarick; Ramani Ramchandran
Journal:  Front Physiol       Date:  2021-02-12       Impact factor: 4.566
  8 in total

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