| Literature DB >> 17294161 |
H S Schaaf1, T C Victor, E Engelke, W Brittle, B J Marais, A C Hesseling, P D van Helden, P R Donald.
Abstract
The aim of the study presented here was to determine the minimal inhibitory concentration of isoniazid for strains of isoniazid-resistant or multidrug-resistant Mycobacterium tuberculosis isolated from children in the Western Cape Province of South Africa. During the period March 2003-October 2005, 45 INH-resistant M. tuberculosis isolates (21 also rifampicin-resistant) were cultured from children less than 13 years of age. Drug susceptibility testing by the radiometric BACTEC 460 method found 11 isolates resistant at 0.1 microg/ml, 27 resistant at 0.2 microg/ml, and seven resistant at > or =5 microg/ml. Thus, the minimal inhibitory concentration of isoniazid for more than 80% of the isoniazid-resistant strains isolated from children in this study was relatively low and could be exceeded by high-dose (15-20 mg/kg) isoniazid regimens.Entities:
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Year: 2007 PMID： 17294161 DOI： 10.1007/s10096-007-0257-9
Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267