Literature DB >> 17294125

Metals ions and neurodegeneration.

Francisco Molina-Holgado1, Robert C Hider, Alessandra Gaeta, Robert Williams, Paul Francis.   

Abstract

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.

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Year:  2007        PMID： 17294125     DOI： 10.1007/s10534-006-9033-z

Source DB:  PubMed          Journal:  Biometals        ISSN： 0966-0844            Impact factor:   2.949


  45 in total

1.  Early post-natal iron administration induces astroglial response in the brain of adult and aged rats.

Authors:  Liana Lisboa Fernandez; Maria Noêmia Martins de Lima; Felipe Scalco; Gustavo Vedana; Clívia Miwa; Arlete Hilbig; Mônica Vianna; Nadja Schröder
Journal:  Neurotox Res       Date:  2010-12-17       Impact factor: 3.911

2.  Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.

Authors:  Joseph J Braymer; Jung-Suk Choi; Alaina S DeToma; Chen Wang; Kisoo Nam; Jeffrey W Kampf; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal:  Inorg Chem       Date:  2011-09-28       Impact factor: 5.165

3.  Effect of cerebral amyloid angiopathy on brain iron, copper, and zinc in Alzheimer's disease.

Authors:  Matthew Schrag; Andrew Crofton; Matthew Zabel; Arshad Jiffry; David Kirsch; April Dickson; Xiao Wen Mao; Harry V Vinters; Dylan W Domaille; Christopher J Chang; Wolff Kirsch
Journal:  J Alzheimers Dis       Date:  2011       Impact factor: 4.472

Review 4.  Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration.

Authors:  Romana Fato; Christian Bergamini; Serena Leoni; Paola Strocchi; Giorgio Lenaz
Journal:  Neurochem Res       Date:  2008-06-06       Impact factor: 3.996

Review 5.  Redox control of prion and disease pathogenesis.

Authors:  Neena Singh; Ajay Singh; Dola Das; Maradumane L Mohan
Journal:  Antioxid Redox Signal       Date:  2010-06-01       Impact factor: 8.401

6.  Small molecule modulators of copper-induced Abeta aggregation.

Authors:  Sarmad S Hindo; Allana M Mancino; Joseph J Braymer; Yihong Liu; Subramanian Vivekanandan; Ayyalusamy Ramamoorthy; Mi Hee Lim
Journal:  J Am Chem Soc       Date:  2009-11-25       Impact factor: 15.419

Review 7.  Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.

Authors:  Orly Weinreb; Silvia Mandel; Orit Bar-Am; Tamar Amit
Journal:  J Neural Transm (Vienna)       Date:  2011-03-01       Impact factor: 3.575

8.  Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases.

Authors:  Muralidhar L Hegde; Pavana M Hegde; Luis M F Holthauzen; Tapas K Hazra; K S Jagannatha Rao; Sankar Mitra
Journal:  J Biol Chem       Date:  2010-07-09       Impact factor: 5.157

9.  Paradoxical role of prion protein aggregates in redox-iron induced toxicity.

Authors:  Dola Das; Xiu Luo; Ajay Singh; Yaping Gu; Soumya Ghosh; Chinmay K Mukhopadhyay; Shu G Chen; Man-Sun Sy; Qingzhong Kong; Neena Singh
Journal:  PLoS One       Date:  2010-07-06       Impact factor: 3.240

10.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063
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