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Literature DB >> 17293400

The thermodynamics of general anesthesia.

Abstract

It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule, which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model accounts for the pressure reversal of anesthesia in a quantitative manner. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia.

Entities: Disease

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Year: 2007 PMID： 17293400 PMCID： PMC1852341 DOI： 10.1529/biophysj.106.099754

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

34 in total

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Authors: Y Kaminoh; N Kitagawa; S Nishimura; H Kamaya; I Ueda
Journal: Ann N Y Acad Sci Date: 1991 Impact factor: 5.691

2. Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversal.

Authors: G W Moss; W R Lieb; N P Franks
Journal: Biophys J Date: 1991-12 Impact factor: 4.033

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Authors: Y Kaminoh; S Nishimura; H Kamaya; I Ueda
Journal: Biochim Biophys Acta Date: 1992-05-21

Review 4. Molecular and cellular mechanisms of general anaesthesia.

Authors: N P Franks; W R Lieb
Journal: Nature Date: 1994-02-17 Impact factor: 49.962

5. The stability of solitons in biomembranes and nerves.

Authors: B Lautrup; R Appali; A D Jackson; T Heimburg
Journal: Eur Phys J E Soft Matter Date: 2011-06-09 Impact factor: 1.890

Review 6. The lateral pressure profile in membranes: a physical mechanism of general anesthesia.

Authors: R S Cantor
Journal: Biochemistry Date: 1997-03-04 Impact factor: 3.162

Review 7. Lipid vs protein theories of alcohol action in the nervous system.

Authors: R W Peoples; C Li; F F Weight
Journal: Annu Rev Pharmacol Toxicol Date: 1996 Impact factor: 13.820

8. Passive ion permeability of lipid membranes modelled via lipid-domain interfacial area.

Authors: L Cruzeiro-Hansson; O G Mouritsen
Journal: Biochim Biophys Acta Date: 1988-09-15

9. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model.

Authors: L Langerman; M Bansinath; G J Grant
Journal: Anesth Analg Date: 1994-09 Impact factor: 5.108

10. Evaluation of pH changes in inflammation of the subcutaneous air pouch lining in the rat, induced by carrageenan, dextran and Staphylococcus aureus.

Authors: A Punnia-Moorthy
Journal: J Oral Pathol Date: 1987-01

29 in total

1. Bubbles, gating, and anesthetics in ion channels.

Authors: Roland Roth; Dirk Gillespie; Wolfgang Nonner; Robert E Eisenberg
Journal: Biophys J Date: 2008-01-30 Impact factor: 4.033

2. The temperature dependence of lipid membrane permeability, its quantized nature, and the influence of anesthetics.

Authors: Andreas Blicher; Katarzyna Wodzinska; Matthias Fidorra; Mathias Winterhalter; Thomas Heimburg
Journal: Biophys J Date: 2009-06-03 Impact factor: 4.033

3. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle.

Authors: D Di Croce; P W Trinks; M B Grifo; D Takara; G A Sánchez
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2015-07-15 Impact factor: 3.000

4. The stability of solitons in biomembranes and nerves.

Authors: B Lautrup; R Appali; A D Jackson; T Heimburg
Journal: Eur Phys J E Soft Matter Date: 2011-06-09 Impact factor: 1.890

5. The capacitance and electromechanical coupling of lipid membranes close to transitions: the effect of electrostriction.

Authors: Thomas Heimburg
Journal: Biophys J Date: 2012-09-05 Impact factor: 4.033

6. The thermodynamics of general and local anesthesia.

Authors: Kaare Graesbøll; Henrike Sasse-Middelhoff; Thomas Heimburg
Journal: Biophys J Date: 2014-05-20 Impact factor: 4.033

7. Liquid general anesthetics lower critical temperatures in plasma membrane vesicles.

Authors: Ellyn Gray; Joshua Karslake; Benjamin B Machta; Sarah L Veatch
Journal: Biophys J Date: 2013-12-17 Impact factor: 4.033

Review 8. Molecular targets and mechanisms for ethanol action in glycine receptors.

Authors: Daya I Perkins; James R Trudell; Daniel K Crawford; Ronald L Alkana; Daryl L Davies
Journal: Pharmacol Ther Date: 2010-04-23 Impact factor: 12.310

9. Anaesthetics stop diverse plant organ movements, affect endocytic vesicle recycling and ROS homeostasis, and block action potentials in Venus flytraps.

Authors: K Yokawa; T Kagenishi; A Pavlovic; S Gall; M Weiland; S Mancuso; F Baluška
Journal: Ann Bot Date: 2018-11-03 Impact factor: 4.357

10. Correlated volume-energy fluctuations of phospholipid membranes: a simulation study.

Authors: Ulf R Pedersen; Günther H Peters; Thomas B Schrøder; Jeppe C Dyre
Journal: J Phys Chem B Date: 2010-02-18 Impact factor: 2.991