| Literature DB >> 17292889 |
Daria Maria Monti1, Nicola Montesano Gesualdi, Josef Matousek, Franca Esposito, Giuseppe D'Alessio.
Abstract
The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.Entities:
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Year: 2007 PMID： 17292889 DOI： 10.1016/j.febslet.2007.01.072
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124