OBJECTIVES: Zinc concentration is higher in the prostate than in most other tissues. Since information on the role of zinc on prostate carcinogenesis is controversial, we analysed the issue in a case-control study. METHODS: Between 1991 and 2002, we conducted a multicentre hospital-based case-control study on prostate cancer in Italy. Cases included 1294 men with incident, histologically confirmed prostate cancer. Controls included 1451 patients admitted to the same hospitals as cases for a wide spectrum of acute non-neoplastic, non-hormone-related diseases. Zinc intake was computed from a valid and reproducible food frequency questionnaire, with the use of an Italian food composition database. Odds ratios (OR) of dietary intake of zinc and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models, after allowance for several covariates, including total energy. RESULTS: Compared with the lowest quintile, the OR for the highest quintile was 1.56 (95% CI, 1.07-2.26), with a significant trend in risk (p=0.04). The trend in risk was significant for advanced cancers only, the OR being 2.02 (95% CI, 1.14-3.59) for prostate cancers with a high Gleason score. CONCLUSIONS: In this large study we found a direct association between high zinc intake and prostate cancer risk, particularly for advanced cancers. Our findings allow one to exclude a favourable effect of zinc on prostate carcinogenesis.
OBJECTIVES: Zinc concentration is higher in the prostate than in most other tissues. Since information on the role of zinc on prostate carcinogenesis is controversial, we analysed the issue in a case-control study. METHODS: Between 1991 and 2002, we conducted a multicentre hospital-based case-control study on prostate cancer in Italy. Cases included 1294 men with incident, histologically confirmed prostate cancer. Controls included 1451 patients admitted to the same hospitals as cases for a wide spectrum of acute non-neoplastic, non-hormone-related diseases. Zinc intake was computed from a valid and reproducible food frequency questionnaire, with the use of an Italian food composition database. Odds ratios (OR) of dietary intake of zinc and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models, after allowance for several covariates, including total energy. RESULTS: Compared with the lowest quintile, the OR for the highest quintile was 1.56 (95% CI, 1.07-2.26), with a significant trend in risk (p=0.04). The trend in risk was significant for advanced cancers only, the OR being 2.02 (95% CI, 1.14-3.59) for prostate cancers with a high Gleason score. CONCLUSIONS: In this large study we found a direct association between high zinc intake and prostate cancer risk, particularly for advanced cancers. Our findings allow one to exclude a favourable effect of zinc on prostate carcinogenesis.
Authors: Jan Hrabeta; Tomas Eckschlager; Marie Stiborova; Zbynek Heger; Sona Krizkova; Vojtech Adam Journal: J Mol Med (Berl) Date: 2016-09-16 Impact factor: 4.599
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Authors: Yuqing Zhang; Patricia Coogan; Julie R Palmer; Brian L Strom; Lynn Rosenberg Journal: Cancer Causes Control Date: 2008-12-18 Impact factor: 2.506
Authors: Maulik R Shah; Christopher L Kriedt; Nathan H Lents; Mary K Hoyer; Nimah Jamaluddin; Claudette Klein; Joseph Baldassare Journal: J Exp Clin Cancer Res Date: 2009-06-17