Literature DB >> 1729223

Nitrogen catabolite repression of arginase (CAR1) expression in Saccharomyces cerevisiae is derived from regulated inducer exclusion.

T G Cooper1, L Kovari, R A Sumrada, H D Park, R M Luche, I Kovari.   

Abstract

Expression of the Saccharomyces cerevisiae arginase (CAR1) gene is regulated by induction and nitrogen catabolite repression (NCR). Arginine was demonstrated to be the native inducer. CAR1 sensitivity to NCR has long been accepted to be accomplished through a negative control mechanism, and cis-acting sites for it have been hypothesized. In search of this negatively acting site, we discovered that CAR1 sensitivity to NCR derives from regulated inducer (arginine) exclusion. The route of catabolic entry of arginine into the cell, the general amino acid permease (GAP1), is sensitive to NCR. However, CAR1 expression in the presence of sufficient intracellular arginine is NCR insensitive.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1729223      PMCID： PMC205675          DOI： 10.1128/jb.174.1.48-55.1992

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  28 in total

1.  The DAL7 promoter consists of multiple elements that cooperatively mediate regulation of the gene's expression.

Authors:  H S Yoo; T G Cooper
Journal:  Mol Cell Biol       Date:  1989-08       Impact factor: 4.272

2.  THE PATHWAY OF ARGININE BREAKDOWN IN SACCHAROMYCES CEREVISIAE.

Authors:  W J MIDDELHOVEN
Journal:  Biochim Biophys Acta       Date:  1964-12-09

3.  Identification of sequences responsible for transcriptional activation of the allantoate permease gene in Saccharomyces cerevisiae.

Authors:  R Rai; F S Genbauffe; R A Sumrada; T G Cooper
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

4.  C-terminal sequences can inhibit the insertion of membrane proteins into the endoplasmic reticulum of Saccharomyces cerevisiae.

Authors:  N Green; P Walter
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

5.  Upstream induction sequence, the cis-acting element required for response to the allantoin pathway inducer and enhancement of operation of the nitrogen-regulated upstream activation sequence in Saccharomyces cerevisiae.

Authors:  H J van Vuuren; J R Daugherty; R Rai; T G Cooper
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490

6.  Participation of ABF-1 protein in expression of the Saccharomyces cerevisiae CAR1 gene.

Authors:  L Z Kovari; T G Cooper
Journal:  J Bacteriol       Date:  1991-10       Impact factor: 3.490

7.  Point mutation generates constitutive expression of an inducible eukaryotic gene.

Authors:  R A Sumrada; T G Cooper
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

8.  Requirement of upstream activation sequences for nitrogen catabolite repression of the allantoin system genes in Saccharomyces cerevisiae.

Authors:  T G Cooper; R Rai; H S Yoo
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

9.  Determination of the DNA-binding sequences of ARGR proteins to arginine anabolic and catabolic promoters.

Authors:  F Messenguy; E Dubois; C Boonchird
Journal:  Mol Cell Biol       Date:  1991-05       Impact factor: 4.272

10.  Saturation mutagenesis of the UASNTR (GATAA) responsible for nitrogen catabolite repression-sensitive transcriptional activation of the allantoin pathway genes in Saccharomyces cerevisiae.

Authors:  N Bysani; J R Daugherty; T G Cooper
Journal:  J Bacteriol       Date:  1991-08       Impact factor: 3.490
View more
  9 in total

1.  Saccharomyces cerevisiae GATA sequences function as TATA elements during nitrogen catabolite repression and when Gln3p is excluded from the nucleus by overproduction of Ure2p.

Authors:  K H Cox; R Rai; M Distler; J R Daugherty; J A Coffman; T G Cooper
Journal:  J Biol Chem       Date:  2000-06-09       Impact factor: 5.157

2.  Participation of RAP1 protein in expression of the Saccharomyces cerevisiae arginase (CAR1) gene.

Authors:  L Z Kovari; I Kovari; T G Cooper
Journal:  J Bacteriol       Date:  1993-02       Impact factor: 3.490

3.  Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae.

Authors:  J R Daugherty; R Rai; H M el Berry; T G Cooper
Journal:  J Bacteriol       Date:  1993-01       Impact factor: 3.490

4.  A regulatory element in the CHA1 promoter which confers inducibility by serine and threonine on Saccharomyces cerevisiae genes.

Authors:  C Bornaes; M W Ignjatovic; P Schjerling; M C Kielland-Brandt; S Holmberg
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272

5.  Metabolic engineering of arginine permeases to reduce the formation of urea in Saccharomyces cerevisiae.

Authors:  Peng Zhang; Xing Hu
Journal:  World J Microbiol Biotechnol       Date:  2018-03-13       Impact factor: 3.312

Review 6.  Nitrogen catabolite repression in Saccharomyces cerevisiae.

Authors:  J Hofman-Bang
Journal:  Mol Biotechnol       Date:  1999-08       Impact factor: 2.695

7.  Combinatorial regulation of the Saccharomyces cerevisiae CAR1 (arginase) promoter in response to multiple environmental signals.

Authors:  W C Smart; J A Coffman; T G Cooper
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

8.  Tripartite structure of the Saccharomyces cerevisiae arginase (CAR1) gene inducer-responsive upstream activation sequence.

Authors:  M Viljoen; L Z Kovari; I A Kovari; H D Park; H J van Vuuren; T G Cooper
Journal:  J Bacteriol       Date:  1992-11       Impact factor: 3.490

9.  An alternative, arginase-independent pathway for arginine metabolism in Kluyveromyces lactis involves guanidinobutyrase as a key enzyme.

Authors:  G Romagnoli; M D Verhoeven; R Mans; Y Fleury Rey; R Bel-Rhlid; M van den Broek; R Maleki Seifar; A Ten Pierick; M Thompson; V Müller; S A Wahl; J T Pronk; J M Daran
Journal:  Mol Microbiol       Date:  2014-06-23       Impact factor: 3.501
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.