| Literature DB >> 17291739 |
J Chen1, W L Li, J L Wu, B R Ren, H Q Zhang.
Abstract
Sesquiterpene glycoside, nerolidol-3-O-alpha-l-rhamnopyranosyl(1-->4)-alpha-l-rhamnopyranosyl(1-->2)-[alpha-l-rhamnopyranosyl(1-->6)]-beta-d-glucopyranoside was isolated from dried leaves of loquat [Eriobotrya japonica (Thunb.) Lindl., Rosaceae]. Hypoglycemic effects of this natural product were assessed in normal and alloxan-diabetic mice model. Animals received orally administration of the sesquiterpene glycoside in dose of 25 and 75 mg/kg. The anti-hyperglycemic effect was compared with gliclazide's. The dose of 25 and 75 mg/kg both exerted a significant (p<0.05) hypoglycemic effect in alloxan-diabetic mice throughout the test and a slight effect in normal mice.Entities:
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Year: 2007 PMID： 17291739 DOI： 10.1016/j.phymed.2006.12.014
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340