Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.

Literature DB >> 1729171

Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.

Abstract

The HLA-A9 family has been characterized as possessing two well defined specificities; HLA-A23 and A24. Serological studies have suggested the presence of a third member of this family HLA-A9.3, however there is doubt surrounding the existence of this specificity. HLA-A23, A24, and the putative A9.3 proteins were analyzed biochemically by immunoprecipitation and isoelectric focusing. Both HLA-A24 and A9.3 have identical isoelectric points whereas A23 is different. We have sequenced cDNA encoding HLA-A23, A24, and A9.3. From the observed protein sequences, we found A9.3 to differ from A24 by two amino acid substitutions located in the alpha 2 helix of the class I molecule. These substitutions are expected to significantly change the shape of the peptide binding cleft.

Mesh：

Substances：

Year: 1992 PMID： 1729171 DOI： 10.1007/bf00216625

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

11 in total

Review 1. Structure, function, and diversity of class I major histocompatibility complex molecules.

Authors: P J Bjorkman; P Parham
Journal: Annu Rev Biochem Date: 1990 Impact factor: 23.643

2. DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells.

Authors: E P Cowan; M L Jelachich; W E Biddison; J E Coligan
Journal: Immunogenetics Date: 1987 Impact factor: 2.846

3. Specificity pockets for the side chains of peptide antigens in HLA-Aw68.

Authors: T P Garrett; M A Saper; P J Bjorkman; J L Strominger; D C Wiley
Journal: Nature Date: 1989-12-07 Impact factor: 49.962

4. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes.

Authors: J J Neefjes; B S Breur-Vriesendorp; G A van Seventer; P Iványi; H L Ploegh
Journal: Hum Immunol Date: 1986-06 Impact factor: 2.850

5. The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes.

Authors: C N'Guyen; R Sodoyer; J Trucy; T Strachan; B R Jordan
Journal: Immunogenetics Date: 1985 Impact factor: 2.846

6. Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

Authors: P D Ennis; J Zemmour; R D Salter; P Parham
Journal: Proc Natl Acad Sci U S A Date: 1990-04 Impact factor: 11.205

7. HLA-AR, an inactivated antigen-presenting locus related to HLA-A. Implications for the evolution of the MHC.

Authors: J Zemmour; B H Koller; P D Ennis; D E Geraghty; D A Lawlor; H T Orr; P Parham
Journal: J Immunol Date: 1990-05-01 Impact factor: 5.422

8. Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30.

Authors: K Kato; J A Trapani; J Allopenna; B Dupont; S Y Yang
Journal: J Immunol Date: 1989-11-15 Impact factor: 5.422

4. Direct binding to antigen-coated beads refines the specificity and cross-reactivity of four monoclonal antibodies that recognize polymorphic epitopes of HLA class I molecules.

Authors: H G Hilton; P Parham
Journal: Tissue Antigens Date: 2013-04

5. Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C.

Authors: J Zemmour; P Parham
Journal: J Exp Med Date: 1992-10-01 Impact factor: 14.307

5 in total

Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.

Review 1. Structure, function, and diversity of class I major histocompatibility complex molecules.

2. DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells.

3. Specificity pockets for the side chains of peptide antigens in HLA-Aw68.

4. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes.

5. The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes.

6. Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

7. HLA-AR, an inactivated antigen-presenting locus related to HLA-A. Implications for the evolution of the MHC.

8. Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30.

9. The genetics of transplantation antigens.

Review 10. Structure and diversity of class I antigen presenting molecules in the mouse.

1. Nomenclature for factors of the HLA system, 1991. The WHO Nomenclature Committee for factors of the HLA system.

2. A region of primer binding variation at the D6S265 locus associated with HLA-A25 and HLA-A26 antigens.

3. Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/A11 family.

4. Direct binding to antigen-coated beads refines the specificity and cross-reactivity of four monoclonal antibodies that recognize polymorphic epitopes of HLA class I molecules.

5. Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C.