Joshua D Mitchell1, E Sherwood Brown, A John Rush. 1. UT Southwestern Medical Center at Dallas, Department of Psychiatry, 5323 Harry Hines Blvd., Dallas, TX 75390-8849, USA. joshua.mitchell@utsouthwestern.edu
Abstract
OBJECTIVE: Substance dependence is common in bipolar disorder and is associated with an increase in Axis I and II comorbidity. Little research has compared the relative rates of comorbidity among bipolar patients with dependence on different substances. METHODS: The Mini International Neuropsychiatric Interview (MINI) was used to assess 166 outpatients involved in one of three clinical trials of medications for bipolar disorder and substance dependence. Patients had concurrent alcohol dependence, cocaine dependence, or both conditions. RESULTS: Generalized anxiety disorder and current depressed mood were significantly more common in bipolar patients with alcohol dependence than bipolar patients with cocaine dependence. Those with cocaine dependence had significantly higher rates of post-traumatic stress disorder and antisocial personality disorder and were more likely to present in a mixed mood state than patients dependent on alcohol. Cocaine ENC dependent patients were more likely than alcohol dependent patients to have Bipolar I relative to Bipolar II. LIMITATIONS: This is a retrospective, cross-sectional data analysis using the MINI for diagnosis. CONCLUSIONS: Cocaine dependence and alcohol dependence were associated with different clinical features and comorbid disorders in bipolar patients. The results may help confirm the validity of integrative models of mood, behavioral, anxiety, and personality disorders. Further studies on the causal relationship between substance dependence and concurrent and lifetime Axis I disorders for patients with bipolar disorders are indicated.
OBJECTIVE: Substance dependence is common in bipolar disorder and is associated with an increase in Axis I and II comorbidity. Little research has compared the relative rates of comorbidity among bipolarpatients with dependence on different substances. METHODS: The Mini International Neuropsychiatric Interview (MINI) was used to assess 166 outpatients involved in one of three clinical trials of medications for bipolar disorder and substance dependence. Patients had concurrent alcohol dependence, cocaine dependence, or both conditions. RESULTS: Generalized anxiety disorder and current depressed mood were significantly more common in bipolarpatients with alcohol dependence than bipolarpatients with cocaine dependence. Those with cocaine dependence had significantly higher rates of post-traumatic stress disorder and antisocial personality disorder and were more likely to present in a mixed mood state than patients dependent on alcohol. Cocaine ENC dependent patients were more likely than alcohol dependent patients to have Bipolar I relative to Bipolar II. LIMITATIONS: This is a retrospective, cross-sectional data analysis using the MINI for diagnosis. CONCLUSIONS:Cocaine dependence and alcohol dependence were associated with different clinical features and comorbid disorders in bipolarpatients. The results may help confirm the validity of integrative models of mood, behavioral, anxiety, and personality disorders. Further studies on the causal relationship between substance dependence and concurrent and lifetime Axis I disorders for patients with bipolar disorders are indicated.
Authors: Elizabeth L George; David J Miklowitz; Jeffrey A Richards; Teresa L Simoneau; Dawn O Taylor Journal: Bipolar Disord Date: 2003-04 Impact factor: 6.744
Authors: Renee D Goodwin; David A Stayner; Matthew J Chinman; Ping Wu; Jacob Kraemer Tebes; Larry Davidson Journal: Compr Psychiatry Date: 2002 Jul-Aug Impact factor: 3.735
Authors: Roger D Weiss; Monika Kolodziej; Margaret L Griffin; Lisa M Najavits; Lara M Jacobson; Shelly F Greenfield Journal: J Affect Disord Date: 2004-04 Impact factor: 4.839
Authors: E Sherwood Brown; Prabha Sunderajan; Lisa T Hu; Sharon M Sowell; Thomas J Carmody Journal: Neuropsychopharmacology Date: 2012-06-06 Impact factor: 7.853
Authors: Keming Gao; Philip K Chan; Marcia L Verduin; David E Kemp; Bryan K Tolliver; Stephen J Ganocy; Sarah Bilali; Kathleen T Brady; Robert L Findling; Joseph R Calabrese Journal: Am J Addict Date: 2010 Sep-Oct
Authors: Maria A Oquendo; Dianne Currier; Shang-Min Liu; Deborah S Hasin; Bridget F Grant; Carlos Blanco Journal: J Clin Psychiatry Date: 2010-07 Impact factor: 4.384
Authors: Timothy E Wilens; Diana W Woodward; Je Deuk Ko; Amy F Berger; Colin Burke; Amy M Yule Journal: J Child Adolesc Psychopharmacol Date: 2022-05-04 Impact factor: 3.031
Authors: Peter R Martin; Amelia M Arria; Gabriele Fischer; Karol Kaltenbach; Sarah H Heil; Susan M Stine; Mara G Coyle; Peter Selby; Hendrée E Jones Journal: Am J Addict Date: 2009 Mar-Apr
Authors: Keming Gao; Marcia L Verduin; David E Kemp; Bryan K Tolliver; Stephen J Ganocy; Omar Elhaj; Sarah Bilali; Kathleen T Brady; Robert L Findling; Joseph R Calabrese Journal: J Clin Psychiatry Date: 2008-07 Impact factor: 4.384
Authors: Alexandra K Gold; Amy T Peters; Michael W Otto; Louisa G Sylvia; Pedro Vieira da Silva Magalhaes; Michael Berk; Darin D Dougherty; David J Miklowitz; Ellen Frank; Andrew A Nierenberg; Thilo Deckersbach Journal: Aust N Z J Psychiatry Date: 2018-07-26 Impact factor: 5.744