Literature DB >> 172911

Cytochemical study of secretory process in transplantable insulinoma of syrian golden hamster.

A B Novikoff, A Yam, P M Novikoff.   

Abstract

Electron microscopy, including phosphatase cytochemistry, indicates that the secretory granules of an insulinoma producing proinsulin and insulin are packaged by the endoplasmic reticulum (ER) and especially by a specialized region of ER which we call GERL because of the spatial relationship of this region to the Golgi apparatus and its apparent role in producing lysosomes. The granules are not derived from the Golgi apparatus. Preliminary evidence suggests this may be true also of pancreatic beta-cells.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 172911      PMCID： PMC388750          DOI： 10.1073/pnas.72.11.4501

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

Review 1.  Intracellular aspects of the process of protein synthesis.

Authors:  G Palade
Journal:  Science       Date:  1975-08-01       Impact factor: 47.728

2.  Pathological changes in cytoplasmic organelles.

Authors:  A B NOVIKOFF; E ESSNER
Journal:  Fed Proc       Date:  1962 Nov-Dec

3.  Regulation of in vitro insulin release from a transplantable Syrian hamster insulinoma.

Authors:  S Shapiro; S Eto; N Fleischer; S G Baum
Journal:  Endocrinology       Date:  1975-08       Impact factor: 4.736

Review 4.  Microperoxisomes.

Authors:  A B Novikoff; P M Novikoff
Journal:  J Histochem Cytochem       Date:  1973-11       Impact factor: 2.479

5.  Acid phosphatase activity in secretory granules of pancreatic beta cells of normal rats.

Authors:  L Orci; W Stauffacher; C Rufener; A E Lambert; C Rouiller; A E Renold
Journal:  Diabetes       Date:  1971-06       Impact factor: 9.461

6.  Studies on microperoxisomes. II. A cytochemical method for light and electron microscopy.

Authors:  A B Novikoff; P M Novikoff; C Davis; N Quintana
Journal:  J Histochem Cytochem       Date:  1972-12       Impact factor: 2.479

7.  [The localization of peroxidase and acid phosphatase in eosinophil leukocytes during maturation. Electron microscopical cytochemical studies on the bone marrow of the rat and rabbit].

Authors:  F Miller; V Herzog
Journal:  Z Zellforsch Mikrosk Anat       Date:  1969

8.  Localization of acid phosphatase activity and secretion mechanism in rabbit pancreatic B-cells.

Authors:  S S Lazarus; B W Volk; H Barden
Journal:  J Histochem Cytochem       Date:  1966-03       Impact factor: 2.479

9.  Cytochemical studies on golgi apparatus, GERL, and lysosomes in neurons of dorsal root ganglia in mice.

Authors:  J M Boutry; A B Nivikoff
Journal:  Proc Natl Acad Sci U S A       Date:  1975-02       Impact factor: 11.205

10.  Golgi apparatus, GERL, and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry.

Authors:  P M Novikoff; A B Novikoff; N Quintana; J J Hauw
Journal:  J Cell Biol       Date:  1971-09       Impact factor: 10.539
View more
  15 in total

1.  Cytochemical contributions to differentiating GERL from the Golgi apparatus.

Authors:  A B Novikoff; P M Novikoff
Journal:  Histochem J       Date:  1977-09

Review 2.  The endoplasmic reticulum: a cytochemist's view (a review).

Authors:  A B Novikoff
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

3.  Lysosomes in normal pancreatic beta cells.

Authors:  P Meda
Journal:  Diabetologia       Date:  1978-05       Impact factor: 10.122

4.  Cytochemical studies of GERL and its role in secretory granule formation in exocrine cells.

Authors:  A R Hand; C Oliver
Journal:  Histochem J       Date:  1977-07

5.  Secretory granules of B-cells in the synovial membrane. An ultrastructural and cytochemical study.

Authors:  Y Okada; I Nakanishi; K Kajikawa
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249

6.  Cytochemical studies on the internal polarity of the Golgi apparatus and the relationship between this organelle and GERL.

Authors:  F Sawano; H Fujita
Journal:  Histochemistry       Date:  1981

7.  The fine localization of acid phosphatase activity in the unvacuolated notochordal cells of the early chick embryo.

Authors:  T Kayahara
Journal:  Histochem J       Date:  1982-05

8.  Fine structural localization of thiamine pyrophosphatase and acid phosphatase activities in the mouse pancreatic acinar cell.

Authors:  H Fujita; H Okamoto
Journal:  Histochemistry       Date:  1979

9.  Comparison of prohormone-processing activities in islet microsomes and secretory granules: evidence for distinct converting enzymes for separate islet prosomatostatins.

Authors:  B D Noe; G Debo; J Spiess
Journal:  J Cell Biol       Date:  1984-08       Impact factor: 10.539

10.  Golgi apparatus, GERL, and secretory granule formation within neurons of the hypothalamo-neurohypophysial system of control and hyperosmotically stressed mice.

Authors:  R D Broadwell; C Oliver
Journal:  J Cell Biol       Date:  1981-08       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.