OBJECTIVE: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients. METHOD:BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up). RESULTS:Eleven age- and disease severity-matched PD patients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. CONCLUSION:BTX-A injections to the legs did not improve FOG and might increase fall risk.
RCT Entities:
OBJECTIVE: To assess the effect on freezing of gait (FOG) of botulinum toxin type A (BTX-A) injections in advanced Parkinson's disease (PD) patients. METHOD: BTX-A 150 IU or normal saline was injected into each leg's calf muscles by a blinded investigator. FOG severity was assessed at set intervals (6-month follow-up). RESULTS: Eleven age- and disease severity-matched PDpatients with disabling FOG participated. Six patients received BTX-A and 5 received saline. No improvement was observed in either group over time. Leg weakness and falls lead to early termination. CONCLUSION: BTX-A injections to the legs did not improve FOG and might increase fall risk.
Authors: Gonzalo J Revuelta; Subramaniam Uthayathas; Amy E Wahlquist; Stewart A Factor; Stella M Papa Journal: Exp Neurol Date: 2012-08-07 Impact factor: 5.330
Authors: Natalie E Allen; Colleen G Canning; Lorena Rosa S Almeida; Bastiaan R Bloem; Samyra Hj Keus; Niklas Löfgren; Alice Nieuwboer; Geert Saf Verheyden; Tiê P Yamato; Catherine Sherrington Journal: Cochrane Database Syst Rev Date: 2022-06-06