Literature DB >> 17289961

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

N Chartrel1, R Alvear-Perez, J Leprince, X Iturrioz, A Reaux-Le Goazigo, V Audinot, P Chomarat, F Coge, O Nosjean, M Rodriguez, J P Galizzi, J A Boutin, H Vaudry, C Llorens-Cortes.   

Abstract

Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

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Year:  2007        PMID： 17289961     DOI： 10.1126/science.1135047

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

Review 1.  GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions.

Authors:  Petra Popovics; Alan J Stewart
Journal:  Cell Mol Life Sci       Date:  2010-09-02       Impact factor: 9.261

Review 2.  The ghrelin/GOAT/GHS-R system and energy metabolism.

Authors:  Chung Thong Lim; Blerina Kola; Márta Korbonits
Journal:  Rev Endocr Metab Disord       Date:  2011-09       Impact factor: 6.514

Review 3.  G protein-coupled receptor deorphanizations.

Authors:  Olivier Civelli; Rainer K Reinscheid; Yan Zhang; Zhiwei Wang; Robert Fredriksson; Helgi B Schiöth
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012-09-28       Impact factor: 13.820

4.  The gastrointestinal peptide obestatin induces vascular relaxation via specific activation of endothelium-dependent NO signalling.

Authors:  Andrew J Agnew; Emma Robinson; Carmel M McVicar; Adam P Harvey; Imran H A Ali; Jennifer E Lindsay; Denise M McDonald; Brian D Green; David J Grieve
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

5.  Effect of peripheral obestatin on food intake and gastric emptying in ghrelin-knockout mice.

Authors:  I Depoortere; T Thijs; D Moechars; B De Smet; L Ver Donck; T L Peeters
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739

6.  Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents.

Authors:  Peter Kobelt; Anna-Sophia Wisser; Andreas Stengel; Miriam Goebel; Norbert Bannert; Guillaume Gourcerol; Tobias Inhoff; Steffen Noetzel; Bertram Wiedenmann; Burghard F Klapp; Yvette Taché; Hubert Mönnikes
Journal:  Peptides       Date:  2008-02-07       Impact factor: 3.750

7.  G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Authors:  Birgitte Holst; Kristoffer L Egerod; Chunyu Jin; Pia Steen Petersen; Mette Viberg Østergaard; Jacob Hald; A M Ejernaes Sprinkel; Joachim Størling; Thomas Mandrup-Poulsen; Jens J Holst; Peter Thams; Cathrine Orskov; Nils Wierup; Frank Sundler; Ole D Madsen; Thue W Schwartz
Journal:  Endocrinology       Date:  2009-02-12       Impact factor: 4.736

8.  Ghrelin, des-acyl ghrelin, and obestatin: regulatory roles on the gastrointestinal motility.

Authors:  Mineko Fujimiya; Akihiro Asakawa; Koji Ataka; Chih-Yen Chen; Ikuo Kato; Akio Inui
Journal:  Int J Pept       Date:  2010-03-15

Review 9.  Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight.

Authors:  Andreas Stengel; Miriam Goebel; Lixin Wang; Yvette Taché
Journal:  Peptides       Date:  2009-11-26       Impact factor: 3.750

Review 10.  Ghrelin and eating disorders.

Authors:  Deniz Atalayer; Charlisa Gibson; Alexandra Konopacka; Allan Geliebter
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2012-08-30       Impact factor: 5.067
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