Literature DB >> 17289931

Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets.

Abhinav Diwan1, Gerald W Dorn.   

Abstract

Cardiac hypertrophy leads to heart failure, and both conditions can ultimately prove lethal. Here, traditional and novel mechanisms relating hypertrophy and heart failure are described at the physiological, cellular, and molecular levels. The rational application of these mechanistic considerations to therapeutics targeting hypertrophy and heart failure is discussed.

Entities:  

Mesh：

Year:  2007        PMID： 17289931     DOI： 10.1152/physiol.00033.2006

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  83 in total

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2.  β₂-Adrenoceptors, NADPH oxidase, ROS and p38 MAPK: another 'radical' road to heart failure?

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Review 4.  Muscle KATP channels: recent insights to energy sensing and myoprotection.

Authors:  Thomas P Flagg; Decha Enkvetchakul; Joseph C Koster; Colin G Nichols
Journal:  Physiol Rev       Date:  2010-07       Impact factor: 37.312

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Review 6.  High salt intake as a multifaceted cardiovascular disease: new support from cellular and molecular evidence.

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7.  Mitochondrial fission is required for cardiomyocyte hypertrophy mediated by a Ca2+-calcineurin signaling pathway.

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8.  Cardiomyocyte p65 nuclear factor-κB is necessary for compensatory adaptation to pressure overload.

Authors:  Hadi Javan; Amanda M Szucsik; Ling Li; Christin L Schaaf; Mohamed E Salama; Craig H Selzman
Journal:  Circ Heart Fail       Date:  2014-12-05       Impact factor: 8.790

Review 9.  Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy.

Authors:  Kaie Ojamaa
Journal:  Vascul Pharmacol       Date:  2009-12-11       Impact factor: 5.773

10.  Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.

Authors:  Nina Kaludercic; Andrea Carpi; Takahiro Nagayama; Vidhya Sivakumaran; Guangshuo Zhu; Edwin W Lai; Djahida Bedja; Agnese De Mario; Kevin Chen; Kathleen L Gabrielson; Merry L Lindsey; Karel Pacak; Eiki Takimoto; Jean C Shih; David A Kass; Fabio Di Lisa; Nazareno Paolocci
Journal:  Antioxid Redox Signal       Date:  2013-05-22       Impact factor: 8.401
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