Literature DB >> 17287906

Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity.

Bayasi Guleng, Keisuke Tateishi, Miki Ohta, Yoshinari Asaoka, Amarsanaa Jazag, Lian-Jie Lin, Yasuo Tanaka, Motohisa Tada, Motoko Seto, Fumihiko Kanai, Takao Kawabe, Masao Omata.   

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Year:  2007        PMID： 17287906     DOI： 10.1007/s00535-006-1955-2

Source DB:  PubMed          Journal:  J Gastroenterol        ISSN： 0944-1174            Impact factor:   7.527


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  6 in total

1.  p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells.

Authors:  Miki Ohta; Keisuke Tateishi; Fumihiko Kanai; Hirotsugu Watabe; Shintaro Kondo; Bayasi Guleng; Yasuo Tanaka; Yoshinari Asaoka; Amarsanaa Jazag; Jun Imamura; Hideaki Ijichi; Tsuneo Ikenoue; Masataka Sata; Makoto Miyagishi; Kazunari Taira; Minoru Tada; Takao Kawabe; Masao Omata
Journal:  Cancer Res       Date:  2005-12-01       Impact factor: 12.701

2.  Activating Smoothened mutations in sporadic basal-cell carcinoma.

Authors:  J Xie; M Murone; S M Luoh; A Ryan; Q Gu; C Zhang; J M Bonifas; C W Lam; M Hynes; A Goddard; A Rosenthal; E H Epstein; F J de Sauvage
Journal:  Nature       Date:  1998-01-01       Impact factor: 49.962

3.  Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells.

Authors:  Yanhua Zhu; Roberta M James; Audrey Peter; Claire Lomas; Francis Cheung; David J Harrison; Scott A Bader
Journal:  Cancer Lett       Date:  2004-04-30       Impact factor: 8.679

4.  Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.

Authors:  David M Berman; Sunil S Karhadkar; Anirban Maitra; Rocio Montes De Oca; Meg R Gerstenblith; Kimberly Briggs; Antony R Parker; Yutaka Shimada; James R Eshleman; D Neil Watkins; Philip A Beachy
Journal:  Nature       Date:  2003-09-14       Impact factor: 49.962

5.  Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Authors:  J Taipale; J K Chen; M K Cooper; B Wang; R K Mann; L Milenkovic; M P Scott; P A Beachy
Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

6.  A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.

Authors:  H Sasaki; C Hui; M Nakafuku; H Kondoh
Journal:  Development       Date:  1997-04       Impact factor: 6.868
  6 in total
  3 in total

1.  Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.

Authors:  Frédéric Varnat; Arnaud Duquet; Monica Malerba; Marie Zbinden; Christophe Mas; Pascal Gervaz; Ariel Ruiz i Altaba
Journal:  EMBO Mol Med       Date:  2009-09       Impact factor: 12.137

Review 2.  Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy.

Authors:  Chuanqing Wu; Xiaojie Zhu; Weizhen Liu; Tuo Ruan; Kaixiong Tao
Journal:  Onco Targets Ther       Date:  2017-06-30       Impact factor: 4.147

Review 3.  The Role of Smoothened in Cancer.

Authors:  Kuo-Shyang Jeng; I-Shyan Sheen; Chuen-Miin Leu; Ping-Hui Tseng; Chiung-Fang Chang
Journal:  Int J Mol Sci       Date:  2020-09-18       Impact factor: 5.923
  3 in total

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