| Literature DB >> 17287126 |
Takahiro Katoh1, Taichi Akagi, Chie Noguchi, Tetsuya Kajimoto, Manabu Node, Reiko Tanaka, Manabu Nishizawa née Iwamoto, Hironori Ohtsu, Noriyuki Suzuki, Koichi Saito.
Abstract
DL-Standishinal (1), an aromatase inhibitor isolated from Thuja standishii, was synthesized in 15 steps from p-formylanisole via aldol reaction of 12-hydroxy-6,7-secoabieta-8,11,13-trien-6,7-dial (2). In the present study, we found that the aldol condensation of 2 proceeded in excellent yield with the protonic catalyst such as d-camphorsulfonic acid in CH(2)Cl(2). Moreover, structure-activity relationship of 1 and its related compounds was studied and it was revealed that the isomers having cis-configuration on the A/B-ring generally exhibited more potent inhibitory activities against aromatase than those with trans-configuration.Entities:
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Year: 2007 PMID： 17287126 DOI： 10.1016/j.bmc.2007.01.031
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641