OBJECTIVES: The objective was to investigate the alterations in estrogen receptor-alpha and -beta (ER-alpha and ER-beta) in the anterior vaginal wall of women with stress urinary incontinence (SUI). STUDY DESIGN: Samples of the anterior vaginal wall were taken from 57 women, including 12 women with premenopausal SUI (pre-M SUI), 12 with premenopausal control (pre-M control), 19 with postmenopausal SUI (post-M SUI), and 14 with postmenopausal control (post-M control). The expressions of ER-alpha and ER-beta were assayed by immunohistochemistry and quantified with the H-score method. RESULTS: Serum estradiol was significantly lower in the pre-M SUI than in the pre-M control group (P<0.01), but the difference between the post-M SUI and post-M control groups was not significant (P>0.05). ER-alpha in endothelia, smooth muscle cells, and fibrocytes were significantly lower in pre-M SUI than in pre-M control (P<0.01), but there were no significant differences of ER-alpha between the post-M SUI and post-M control groups (P>0.05). ER-beta in endothelia and fibrocytes were significantly lower in the pre-M SUI than in the pre-M control group (P<0.01), and ER-beta in fibrocytes was significantly lower in the post-M SUI than in the post-M control group (P<0.01). CONCLUSIONS: Alterations in serum estradiol and its receptors (ER-alpha and ER-beta) in the anterior vaginal wall were demonstrated, suggesting their involvement in the occurrence of female SUI.
OBJECTIVES: The objective was to investigate the alterations in estrogen receptor-alpha and -beta (ER-alpha and ER-beta) in the anterior vaginal wall of women with stress urinary incontinence (SUI). STUDY DESIGN: Samples of the anterior vaginal wall were taken from 57 women, including 12 women with premenopausal SUI (pre-M SUI), 12 with premenopausal control (pre-M control), 19 with postmenopausal SUI (post-M SUI), and 14 with postmenopausal control (post-M control). The expressions of ER-alpha and ER-beta were assayed by immunohistochemistry and quantified with the H-score method. RESULTS: Serum estradiol was significantly lower in the pre-M SUI than in the pre-M control group (P<0.01), but the difference between the post-M SUI and post-M control groups was not significant (P>0.05). ER-alpha in endothelia, smooth muscle cells, and fibrocytes were significantly lower in pre-M SUI than in pre-M control (P<0.01), but there were no significant differences of ER-alpha between the post-M SUI and post-M control groups (P>0.05). ER-beta in endothelia and fibrocytes were significantly lower in the pre-M SUI than in the pre-M control group (P<0.01), and ER-beta in fibrocytes was significantly lower in the post-M SUI than in the post-M control group (P<0.01). CONCLUSIONS: Alterations in serum estradiol and its receptors (ER-alpha and ER-beta) in the anterior vaginal wall were demonstrated, suggesting their involvement in the occurrence of female SUI.
Authors: Christine Elisabeth Skala; Ilka Brigitte Petry; Stefan Albrich; Alexander Puhl; Gert Naumann; Heinz Koelbl Journal: Int Urogynecol J Date: 2010-11-24 Impact factor: 2.894
Authors: V M Miller; H S Taylor; F Naftolin; J E Manson; C E Gleason; E A Brinton; J M Kling; M I Cedars; N M Dowling; K Kantarci; S M Harman Journal: Climacteric Date: 2020-09-03 Impact factor: 3.005
Authors: Wilke M Post; Joanna Widomska; Hilde Grens; Marieke J H Coenen; Frank M J Martens; Dick A W Janssen; Joanna IntHout; Geert Poelmans; Egbert Oosterwijk; Kirsten B Kluivers Journal: Int J Mol Sci Date: 2022-03-21 Impact factor: 5.923