A computational parameter study of embryo transfer.

Embryo transfer (ET) is the final component of the in vitro fertilization process, and the limiting component to its success rate. The procedure is characterized by considerable technical variations in clinical practice and the effects of these different variations on the overall outcome is little understood. In this article we simulate the embryo transfer procedure based on a 2-dimensional fluid dynamics model and, in a large computational effort, we investigate the sensitivity of embryo placement on an array of procedural parameters. The results support the consensus among practitioners in what is the best choice of procedural factors. Based on the study we propose a set of optimal parameters with which to perform the ET procedure; in addition we suggest a novel technique of volume replacement prior to the catheter withdrawal.