Literature DB >> 17285362

A simple absorption model for dose-escalating studies.

Anders Källén1.   

Abstract

A simple model for absorption that generalizes zero and first order absorption processes is discussed. We show how traditional methods can be used to investigate how reasonable this model is, and discuss the effects of the absorption model on classical PK parameters. The methods are illustrated with two real-life data sets from dose-escalating studies.

Mesh：

Substances：

Year:  2007        PMID： 17285362     DOI： 10.1007/s10928-006-9047-8

Source DB:  PubMed          Journal:  J Pharmacokinet Pharmacodyn        ISSN： 1567-567X            Impact factor:   2.745


  5 in total

1.  Dissolution and absorption modeling: model expansion to simulate the effects of precipitation, water absorption, longitudinally changing intestinal permeability, and controlled release on drug absorption.

Authors:  Kevin C Johnson
Journal:  Drug Dev Ind Pharm       Date:  2003-09       Impact factor: 3.225

Review 2.  Modeling and Monte Carlo simulations in oral drug absorption.

Authors:  Aristides Dokoumetzidis; Kosmas Kosmidis; Panos Argyrakis; Panos Macheras
Journal:  Basic Clin Pharmacol Toxicol       Date:  2005-03       Impact factor: 4.080

3.  Use of fractal geometry to determine effects of surface morphology on drug dissolution.

Authors:  D Farin; D Avnir
Journal:  J Pharm Sci       Date:  1992-01       Impact factor: 3.534

4.  Population pharmacokinetic data and parameter estimation based on their first two statistical moments.

Authors:  S L Beal
Journal:  Drug Metab Rev       Date:  1984       Impact factor: 4.518

5.  Population pharmacokinetic modeling of oral cyclosporin using NONMEM: comparison of absorption pharmacokinetic models and design of a Bayesian estimator.

Authors:  A Rousseau; F Léger; Y Le Meur; F Saint-Marcoux; G Paintaud; M Buchler; P Marquet
Journal:  Ther Drug Monit       Date:  2004-02       Impact factor: 3.681
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.