BACKGROUND: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. DESIGN: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. RESULTS: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. CONCLUSION: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.
BACKGROUND: Treatment-related neurotoxicity has been recognized as a significant problem in patients with primary central nervous system lymphoma (PCNSL) as effective treatment has increased survival rates. There is, however, a paucity of research on cognitive functions in this population. DESIGN: In a review of the literature, a total of 17 articles that described cognitive outcome in adult PCNSL patients were identified. RESULTS: The studies that assessed cognitive functions after whole-brain radiotherapy combined with chemotherapy reported cognitive impairment in most patients. Patients treated with chemotherapy alone had either stable or improved cognitive performance in most studies. Methodological problems, however, limited the ability to ascertain the specific contribution of disease and various treatment interventions to cognitive outcome. On the basis of the literature review, a battery of cognitive and quality-of-life (QoL) measures to be used in prospective clinical trials was proposed. The battery is composed of five standardized neuropsychological tests, covering four domains sensitive to disease and treatment effects (attention, executive functions, memory, psychomotor speed), and QoL questionnaires, and meets criteria for use in collaborative trials. CONCLUSION: The incorporation of formal and systematic cognitive evaluations in PCNSL studies will improve our understanding of treatment-related neurotoxicity in this population.
Authors: Nancy D Doolittle; Edit Dósa; Rongwei Fu; Leslie L Muldoon; Leeza M Maron; Meredith A Lubow; Rose Marie Tyson; Cynthia A Lacy; Dale F Kraemer; Robert W Butler; Edward A Neuwelt Journal: J Clin Oncol Date: 2013-10-07 Impact factor: 44.544
Authors: Denise D Correa; Weiji Shi; Lauren E Abrey; Lisa M Deangelis; Antonio M Omuro; Mariel B Deutsch; Howard T Thaler Journal: Neuro Oncol Date: 2011-10-19 Impact factor: 12.300
Authors: Linda J Burns; Beatrice Abbetti; Stacie D Arnold; Jeffrey Bender; Susan Doughtie; Areej El-Jawahiri; Gloria Gee; Theresa Hahn; Mary M Horowitz; Shirley Johnson; Mark Juckett; Lakshmanan Krishnamurit; Susan Kullberg; C Fred LeMaistre; Alison Loren; Navneet S Majhail; Elizabeth A Murphy; Doug Rizzo; Alva Roche-Green; Wael Saber; Barry A Schatz; Kim Schmit-Pokorny; Bronwen E Shaw; Karen L Syrjala; D Kathryn Tierney; Christina Ullrich; David J Vanness; William A Wood; Ellen M Denzen Journal: Biol Blood Marrow Transplant Date: 2018-02-03 Impact factor: 5.742
Authors: D D Correa; J C Root; R Baser; D Moore; K K Peck; E Lis; T B Shore; H T Thaler; A Jakubowski; N Relkin Journal: Brain Imaging Behav Date: 2013-12 Impact factor: 3.978