Literature DB >> 17284414

Stem cell myths.

Tim Magnus1, Ying Liu, Graham C Parker, Mahendra S Rao.   

Abstract

Stem cells, although difficult to define, hold great promise as tools for understanding development and as therapeutic agents. However, as with any new field, uncritical enthusiasm can outstrip reality. In this review, we have listed nine common myths that we believe affect our approach to evaluating stem cells for therapy. We suggest that careful consideration needs to be given to each of these issues when evaluating a particular cell for its use in therapy. Data need to be collected and reported for failed as well as successful experiments and a rigorous scientific approach taken to evaluate the undeniable promise of stem cell biology.

Mesh:

Year:  2008        PMID: 17284414      PMCID: PMC2605483          DOI: 10.1098/rstb.2006.2009

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN: 0962-8436            Impact factor:   6.237


  111 in total

1.  Transplantation of mammalian olfactory progenitors into chick hosts reveals migration and differentiation potentials dependent on cell commitment.

Authors:  P Durbec; G Rougon
Journal:  Mol Cell Neurosci       Date:  2001-03       Impact factor: 4.314

2.  Analysis of neural stem cells by flow cytometry: cellular differentiation modifies patterns of MHC expression.

Authors:  F H McLaren; C N Svendsen; P Van der Meide; E Joly
Journal:  J Neuroimmunol       Date:  2001-01-01       Impact factor: 3.478

3.  Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS.

Authors:  Angelo C Lepore; Steven S W Han; Carla J Tyler-Polsz; Jingli Cai; Mahendra S Rao; Itzhak Fischer
Journal:  Neuron Glia Biol       Date:  2004-05

Review 4.  Developmental changes in the differentiation capacity of haematopoietic stem cells.

Authors:  C Bonifer; N Faust; H Geiger; A M Müller
Journal:  Immunol Today       Date:  1998-05

5.  Telomerase activity in human germline and embryonic tissues and cells.

Authors:  W E Wright; M A Piatyszek; W E Rainey; W Byrd; J W Shay
Journal:  Dev Genet       Date:  1996

6.  Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice.

Authors:  K Hirokawa; S Kubo; M Utsuyama; C Kurashima; T Sado
Journal:  Cell Immunol       Date:  1986-07       Impact factor: 4.868

7.  The adult T-cell receptor delta-chain is diverse and distinct from that of fetal thymocytes.

Authors:  J F Elliott; E P Rock; P A Patten; M M Davis; Y H Chien
Journal:  Nature       Date:  1988-02-18       Impact factor: 49.962

8.  Mobilized bone marrow cells repair the infarcted heart, improving function and survival.

Authors:  D Orlic; J Kajstura; S Chimenti; F Limana; I Jakoniuk; F Quaini; B Nadal-Ginard; D M Bodine; A Leri; P Anversa
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

9.  Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow.

Authors:  P S Frenette; S Subbarao; I B Mazo; U H von Andrian; D D Wagner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205

10.  Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines.

Authors:  P A Labosky; D P Barlow; B L Hogan
Journal:  Development       Date:  1994-11       Impact factor: 6.868

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  7 in total

Review 1.  Long noncoding RNAs: new players in the molecular mechanism for maintenance and differentiation of pluripotent stem cells.

Authors:  Suman Ghosal; Shaoli Das; Jayprokas Chakrabarti
Journal:  Stem Cells Dev       Date:  2013-05-14       Impact factor: 3.272

2.  RNA: state memory and mediator of cellular phenotype.

Authors:  Junhyong Kim; James Eberwine
Journal:  Trends Cell Biol       Date:  2010-04-09       Impact factor: 20.808

Review 3.  Stem cell therapies for spinal cord injury.

Authors:  Vibhu Sahni; John A Kessler
Journal:  Nat Rev Neurol       Date:  2010-06-15       Impact factor: 42.937

4.  Adult neurogenesis in the crayfish brain: proliferation, migration, and possible origin of precursor cells.

Authors:  Yi Zhang; Silvana Allodi; David C Sandeman; Barbara S Beltz
Journal:  Dev Neurobiol       Date:  2009-06       Impact factor: 3.964

5.  Motoneuron replacement for reinnervation of skeletal muscle in adult rats.

Authors:  Robert M Grumbles; Vania W Almeida; Gizelda T B Casella; Patrick M Wood; Kamondanai Hemstapat; Christine K Thomas
Journal:  J Neuropathol Exp Neurol       Date:  2012-10       Impact factor: 3.685

Review 6.  The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions.

Authors:  Alan Regenberg; Debra J H Mathews; David M Blass; Hilary Bok; Joseph T Coyle; Patrick Duggan; Ruth Faden; Julia Finkel; John D Gearhart; Argye Hillis; Ahmet Hoke; Richard Johnson; Michael Johnston; Jeffrey Kahn; Douglas Kerr; Patricia King; Joanne Kurtzberg; S Matthew Liao; John W McDonald; Guy McKhann; Karin B Nelson; Mahendra Rao; Andrew W Siegel; Kirby Smith; Davor Solter; Hongjun Song; Jeremy Sugarman; Angelo Vescovi; Wise Young; Henry T Greely; Richard J Traystman
Journal:  J Cereb Blood Flow Metab       Date:  2008-08-27       Impact factor: 6.200

Review 7.  Introduction: stem cells and brain repair.

Authors:  Siddharthan Chandran; Maeve Caldwell; Nick Allen
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2008-01-12       Impact factor: 6.237

  7 in total

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