Literature DB >> 17283109

The rag locus of Porphyromonas gingivalis contributes to virulence in a murine model of soft tissue destruction.

Xiaoju Shi1, Shirley A Hanley, Marie-Claire Faray-Kele, Stuart C Fawell, Joseph Aduse-Opoku, Robert A Whiley, Michael A Curtis, Lucinda M C Hall.   

Abstract

The rag locus of Porphyromonas gingivalis encodes a putative TonB-dependent outer membrane receptor, RagA, and a 55-kDa immunodominant antigen, RagB. Inactivation of either ragA or ragB prevented expression of both RagA and RagB. Both the ragA and ragB mutants were significantly less virulent than wild-type strains in a murine model of infection.

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Year:  2007        PMID： 17283109      PMCID： PMC1865673          DOI： 10.1128/IAI.01785-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Heterogeneity of Porphyromonas gingivalis strains in the induction of alveolar bone loss in mice.

Authors:  P J Baker; M Dixon; R T Evans; D C Roopenian
Journal:  Oral Microbiol Immunol       Date:  2000-02

2.  Identification of the major surface protein antigens of Porphyromonas gingivalis using IgG antibody reactivity of periodontal case-control serum.

Authors:  M A Curtis; J M Slaney; R J Carman; N W Johnson
Journal:  Oral Microbiol Immunol       Date:  1991-12

3.  A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis.

Authors:  C A Genco; C W Cutler; D Kapczynski; K Maloney; R R Arnold
Journal:  Infect Immun       Date:  1991-04       Impact factor: 3.441

4.  Sequence diversity and antigenic variation at the rag locus of Porphyromonas gingivalis.

Authors:  Lucinda M C Hall; Stuart C Fawell; Xiaoju Shi; Marie-Claire Faray-Kele; Joseph Aduse-Opoku; Robert A Whiley; Michael A Curtis
Journal:  Infect Immun       Date:  2005-07       Impact factor: 3.441

5.  An experimentally induced phlegmonous abscess by a strain of Bacteroides gingivalis in guinea pigs and mice.

Authors:  P Kastelein; T J van Steenbergen; J M Bras; J de Graaff
Journal:  Antonie Van Leeuwenhoek       Date:  1981-03       Impact factor: 2.271

6.  Production and characterisation of monoclonal antibodies to the principle sonicate antigens of Porphyromonas gingivalis w50.

Authors:  D J Millar; E E Scott; J M Slaney; S U; P Benjamin; M A Curtis
Journal:  FEMS Immunol Med Microbiol       Date:  1993-10

7.  Roles of porphyrins and host iron transport proteins in regulation of growth of Porphyromonas gingivalis W50.

Authors:  T E Bramanti; S C Holt
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490

8.  Virulence of a Porphyromonas gingivalis W83 mutant defective in the prtH gene.

Authors:  H M Fletcher; H A Schenkein; R M Morgan; K A Bailey; C R Berry; F L Macrina
Journal:  Infect Immun       Date:  1995-04       Impact factor: 3.441

9.  Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83.

Authors:  Karen E Nelson; Robert D Fleischmann; Robert T DeBoy; Ian T Paulsen; Derrick E Fouts; Jonathan A Eisen; Sean C Daugherty; Robert J Dodson; A Scott Durkin; Michelle Gwinn; Daniel H Haft; James F Kolonay; William C Nelson; Tanya Mason; Luke Tallon; Jessica Gray; David Granger; Hervé Tettelin; Hong Dong; Jamie L Galvin; Margaret J Duncan; Floyd E Dewhirst; Claire M Fraser
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

10.  Heterogeneity of virulence among strains of Bacteroides gingivalis.

Authors:  M E Neiders; P B Chen; H Suido; H S Reynolds; J J Zambon; M Shlossman; R J Genco
Journal:  J Periodontal Res       Date:  1989-05       Impact factor: 4.419
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  11 in total

1.  Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model.

Authors:  Christina O Igboin; Kevin P Tordoff; Melvin L Moeschberger; Ann L Griffen; Eugene J Leys
Journal:  Infect Immun       Date:  2010-11-01       Impact factor: 3.441

2.  Porphyromonas gingivalis RagB is a proinflammatory signal transducer and activator of transcription 4 agonist.

Authors:  J A Hutcherson; J Bagaitkar; K Nagano; F Yoshimura; H Wang; D A Scott
Journal:  Mol Oral Microbiol       Date:  2015-01-11       Impact factor: 3.563

3.  Tobacco-induced alterations to Porphyromonas gingivalis-host interactions.

Authors:  Juhi Bagaitkar; Lisa R Williams; Diane E Renaud; Manjunatha R Bemakanakere; Mike Martin; David A Scott; Donald R Demuth
Journal:  Environ Microbiol       Date:  2009-01-23       Impact factor: 5.491

4.  The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer.

Authors:  Z Su; F Kong; S Wang; J Chen; R Yin; C Zhou; Y Zhang; Z He; Y Shi; Y Xue; X Shi; L Lu; Q Shao; H Xu
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-03-02       Impact factor: 3.267

5.  Genomic comparison of invasive and rare non-invasive strains reveals Porphyromonas gingivalis genetic polymorphisms.

Authors:  Svetlana Dolgilevich; Brian Rafferty; Darya Luchinskaya; Emil Kozarov
Journal:  J Oral Microbiol       Date:  2011-03-09       Impact factor: 5.474

6.  The core genome of the anaerobic oral pathogenic bacterium Porphyromonas gingivalis.

Authors:  Jorg Brunner; Floyd R A Wittink; Martijs J Jonker; Mark de Jong; Timo M Breit; Marja L Laine; Johannes J de Soet; Wim Crielaard
Journal:  BMC Microbiol       Date:  2010-09-29       Impact factor: 3.605

Review 7.  The RagA and RagB proteins of Porphyromonas gingivalis.

Authors:  Jan Potempa; Mariusz Madej; David A Scott
Journal:  Mol Oral Microbiol       Date:  2021-06-08       Impact factor: 4.107

8.  Enhancing specific-antibody production to the ragB vaccine with GITRL that expand Tfh, IFN-γ(+) T cells and attenuates Porphyromonas gingivalis infection in mice.

Authors:  Dong Zheng; Qiang Sun; Zhaoliang Su; Fanzhi Kong; Xiaoju Shi; Jia Tong; Pei Shen; Tianqing Peng; Shengjun Wang; Huaxi Xu
Journal:  PLoS One       Date:  2013-04-01       Impact factor: 3.240

9.  Prevalence of Porphyromonas gingivalis four rag locus genotypes in patients of orthodontic gingivitis and periodontitis.

Authors:  Yi Liu; Yujie Zhang; Lili Wang; Yang Guo; Shuiqing Xiao
Journal:  PLoS One       Date:  2013-04-04       Impact factor: 3.240

10.  Integrated metagenomics/metaproteomics reveals human host-microbiota signatures of Crohn's disease.

Authors:  Alison R Erickson; Brandi L Cantarel; Regina Lamendella; Youssef Darzi; Emmanuel F Mongodin; Chongle Pan; Manesh Shah; Jonas Halfvarson; Curt Tysk; Bernard Henrissat; Jeroen Raes; Nathan C Verberkmoes; Claire M Fraser; Robert L Hettich; Janet K Jansson
Journal:  PLoS One       Date:  2012-11-28       Impact factor: 3.240
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