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Literature DB >> 17283093

Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.

Amanda C Jacobson¹, Ying Ma, James F Zachary, Janis J Weis, John H Weis.

Abstract

CD21/35(-/-) mice, deficient in CD21 and CD35 (complement receptors 2 and 1, respectively), were infected with Borrelia burgdorferi to assess the role of these receptors in a chronic bacterial infection. Although CD21/35(-/-) mice on both C57BL/6 and BALB/c backgrounds produced less B. burgdorferi-specific antibodies than did wild-type mice, spirochete levels and arthritis severity were similar.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17283093 PMCID： PMC1865699 DOI： 10.1128/IAI.01920-06

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

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References

19 in total

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Mice lacking CD21 and CD35 proteins mount effective immune responses against Borrelia burgdorferi infection.

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