Literature DB >> 17283088

Cloning, expression, and characterization of the superantigen streptococcal pyrogenic exotoxin G from Streptococcus dysgalactiae.

Jizi Zhao1, Tomohito Hayashi, Susanna Saarinen, Anastassios C Papageorgiou, Hidehito Kato, Ken'ichi Imanishi, Teruo Kirikae, Ryo Abe, Takehiko Uchiyama, Tohru Miyoshi-Akiyama.   

Abstract

We identified seven novel variants of streptococcal pyrogenic exotoxin G (SPEGG), a superantigen, in Streptococcus dysgalactiae subsp. dysgalactiae or equisimilis isolates from clinical cases of infection in humans and animals. Phylogenetic analysis of the SPEGG variants indicated two clades in the dendrogram: one composed of variants derived from the bacteria isolated from the humans and the other composed of variants from the bacteria isolated from the animals. Bovine peripheral blood mononuclear cells (PBMCs) were stimulated effectively by recombinant SPEGGs (rSPEGGs) expressed in Escherichia coli, while human PBMCs were not stimulated well by any of the rSPEGGs tested. SPEGGs selectively stimulated bovine T cells bearing Vbeta1,10 and Vbeta4. Bovine serum showed reactivity to the rSPEGG proteins. These results indicated that SPEGGs have properties as superantigens, and it is likely that SPEGGs play a pathogenic role in animals.

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Year:  2007        PMID： 17283088      PMCID： PMC1865666          DOI： 10.1128/IAI.01183-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  36 in total

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Authors:  I C Ojukwu; D W Newton; A E Luque; M Y Kotb; M Menegus
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2.  Lack of mitogenic activity of speG- and speG(dys)-positive Streptococcus dysgalactiae subspecies equisimilis isolates from patients with invasive infections.

Authors:  Claudia M Brandt; Klaus G Schweizer; Regina Holland; Rudolf Lütticken; Bettina S Freyaldenhoven
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3.  Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi.

Authors:  S C Artiushin; J F Timoney; A S Sheoran; S K Muthupalani
Journal:  Microb Pathog       Date:  2002-02       Impact factor: 3.738

4.  Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks.

Authors:  James C Smoot; Kent D Barbian; Jamie J Van Gompel; Laura M Smoot; Michael S Chaussee; Gail L Sylva; Daniel E Sturdevant; Stacy M Ricklefs; Stephen F Porcella; Larye D Parkins; Stephen B Beres; David S Campbell; Todd M Smith; Qing Zhang; Vivek Kapur; Judy A Daly; L George Veasy; James M Musser
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-26       Impact factor: 11.205

5.  Complete genome sequence of an M1 strain of Streptococcus pyogenes.

Authors:  J J Ferretti; W M McShan; D Ajdic; D J Savic; G Savic; K Lyon; C Primeaux; S Sezate; A N Suvorov; S Kenton; H S Lai; S P Lin; Y Qian; H G Jia; F Z Najar; Q Ren; H Zhu; L Song; J White; X Yuan; S W Clifton; B A Roe; R McLaughlin
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

6.  An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections.

Authors:  Malak Kotb; Anna Norrby-Teglund; Allison McGeer; Hesham El-Sherbini; M Tevik Dorak; Ayesha Khurshid; Karen Green; Jeanie Peeples; Judy Wade; Glenys Thomson; Benjamin Schwartz; Donald E Low
Journal:  Nat Med       Date:  2002-11-18       Impact factor: 53.440

7.  Superantigen-like gene(s) in human pathogenic Streptococcus dysgalactiae, subsp equisimilis: genomic localisation of the gene encoding streptococcal pyrogenic exotoxin G (speG(dys)).

Authors:  Svea Sachse; Peter Seidel; Dieter Gerlach; Elisabeth Günther; Jürgen Rödel; Eberhard Straube; Karl-Hermann Schmidt
Journal:  FEMS Immunol Med Microbiol       Date:  2002-10-11

8.  Dissemination of the phage-associated novel superantigen gene speL in recent invasive and noninvasive Streptococcus pyogenes M3/T3 isolates in Japan.

Authors:  Tadayoshi Ikebe; Akihito Wada; Yoshishige Inagaki; Kumiko Sugama; Rieko Suzuki; Daisuke Tanaka; Aki Tamaru; Yoshihiro Fujinaga; Yoshiaki Abe; Yoshikata Shimizu; Haruo Watanabe
Journal:  Infect Immun       Date:  2002-06       Impact factor: 3.441

9.  Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence.

Authors:  Stephen B Beres; Gail L Sylva; Kent D Barbian; Benfang Lei; Jessica S Hoff; Nicole D Mammarella; Meng-Yao Liu; James C Smoot; Stephen F Porcella; Larye D Parkins; David S Campbell; Todd M Smith; John K McCormick; Donald Y M Leung; Patrick M Schlievert; James M Musser
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-16       Impact factor: 11.205

10.  The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation.

Authors:  T Proft; S L Moffatt; K D Weller; A Paterson; D Martin; J D Fraser
Journal:  J Exp Med       Date:  2000-05-15       Impact factor: 14.307
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  12 in total

Review 1.  Streptococcus dysgalactiae subsp. equisimilis bacteremia: an emerging infection.

Authors:  S Rantala
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2014-03-29       Impact factor: 3.267

2.  Virulence gene pool detected in bovine group C Streptococcus dysgalactiae subsp. dysgalactiae isolates by use of a group A S. pyogenes virulence microarray.

Authors:  Márcia G Rato; Andreas Nerlich; René Bergmann; Ricardo Bexiga; Sandro F Nunes; Cristina L Vilela; Ilda Santos-Sanches; Gursharan S Chhatwal
Journal:  J Clin Microbiol       Date:  2011-04-27       Impact factor: 5.948

3.  Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS).

Authors:  Yumi Shimomura; Kayo Okumura; Somay Yamagata Murayama; Junji Yagi; Kimiko Ubukata; Teruo Kirikae; Tohru Miyoshi-Akiyama
Journal:  BMC Genomics       Date:  2011-01-11       Impact factor: 3.969

4.  emm gene diversity, superantigen gene profiles and presence of SlaA among clinical isolates of group A, C and G streptococci from western Norway.

Authors:  B R Kittang; S Skrede; N Langeland; C G Haanshuus; H Mylvaganam
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-11-20       Impact factor: 3.267

5.  Comparative genomic analysis of the Streptococcus dysgalactiae species group: gene content, molecular adaptation, and promoter evolution.

Authors:  Haruo Suzuki; Tristan Lefébure; Melissa Jane Hubisz; Paulina Pavinski Bitar; Ping Lang; Adam Siepel; Michael J Stanhope
Journal:  Genome Biol Evol       Date:  2011-01-31       Impact factor: 3.416

6.  Expression, genetic localization and phylogenic analysis of NAPlr in piscine Streptococcus dysgalactiae subspecies dysgalactiae isolates and their patterns of adherence.

Authors:  M Abdelsalam; M Fujino; A E Eissa; S C Chen; M Warda
Journal:  J Adv Res       Date:  2014-05-22       Impact factor: 10.479

7.  Human group A streptococci virulence genes in bovine group C streptococci.

Authors:  Márcia G Rato; Ricardo Bexiga; Sandro F Nunes; Cristina L Vilela; Ilda Santos-Sanches
Journal:  Emerg Infect Dis       Date:  2010-01       Impact factor: 6.883

8.  Evolutionary paths of streptococcal and staphylococcal superantigens.

Authors:  Kayo Okumura; Yumi Shimomura; Somay Yamagata Murayama; Junji Yagi; Kimiko Ubukata; Teruo Kirikae; Tohru Miyoshi-Akiyama
Journal:  BMC Genomics       Date:  2012-08-17       Impact factor: 3.969

9.  Complete genome sequence of Streptococcus dysgalactiae subsp. equisimilis 167 carrying Lancefield group C antigen and comparative genomics of S. dysgalactiae subsp. equisimilis strains.

Authors:  Shinya Watanabe; Teruo Kirikae; Tohru Miyoshi-Akiyama
Journal:  Genome Biol Evol       Date:  2013       Impact factor: 3.416

10.  Increased cytotoxicity and streptolysin O activity in group G streptococcal strains causing invasive tissue infections.

Authors:  Nikolai Siemens; Bård R Kittang; Bhavya Chakrakodi; Oddvar Oppegaard; Linda Johansson; Trond Bruun; Haima Mylvaganam; Mattias Svensson; Steiner Skrede; Anna Norrby-Teglund
Journal:  Sci Rep       Date:  2015-11-25       Impact factor: 4.379
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