Literature DB >> 17280849

Combining recessions (nystagmus and strabismus) with tenotomy improved visual function and decreased oscillopsia and diplopia in acquired downbeat nystagmus and in horizontal infantile nystagmus syndrome.

Zhong I Wang1, Louis F Dell'Osso, Robert L Tomsak, Jonathan B Jacobs.   

Abstract

PURPOSE: To investigate the effects of combined tenotomy and recession procedures on both acquired downbeat nystagmus and horizontal infantile nystagmus.
METHODS: Patient 1 had downbeat nystagmus with a chin-down (upgaze) position, oscillopsia, strabismus, and diplopia. Asymmetric superior rectus recessions and inferior rectus tenotomies reduced right hypertropia and rotated both eyes downward. Patient 2 had horizontal infantile nystagmus, a 20 degrees left-eye exotropia, and alternating (abducting-eye) fixation. Lateral rectus recessions and medial rectus tenotomies were performed. Horizontal and vertical eye movements were recorded pre- and postsurgically using high-speed digital video. The eXpanded Nystagmus Acuity Function (NAFX) and nystagmus amplitudes and frequencies were measured.
RESULTS: Patient 1: The NAFX peak moved from 10 degrees up to primary position where NAFX values improved 17% and visual acuity increased 25%. Vertical NAFX increased across the -10 degrees to +5 degrees vertical range. Primary-position right hypertropia decreased approximately 50%; foveation time per cycle increased 102%; vertical amplitude, oscillopsia, and diplopia were reduced, and frequency was unchanged. Patient 2: Two lateral, narrow high-NAFX regions (due to alternating fixation) became one broad region with a 43% increase in primary position (acuity increased approximately 92.3%). Diplopia amplitude decreased; convergence and gaze holding were improved. Primary-position right exotropia was reduced; foveation time per cycle increased 257%; horizontal-component amplitude decreased 45.7%, and frequency remained unchanged.
CONCLUSIONS: Combining tenotomy with nystagmus or strabismus recession procedures increased NAFX and visual acuities and reduced diplopia and oscillopsia in downbeat nystagmus and infantile nystagmus.

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Year:  2007        PMID: 17280849     DOI: 10.1016/j.jaapos.2006.10.012

Source DB:  PubMed          Journal:  J AAPOS        ISSN: 1091-8531            Impact factor:   1.220


  6 in total

Review 1.  What we know about the generation of nystagmus and other ocular oscillations: are we closer to identifying therapeutic targets?

Authors:  Rebecca Jane McLean; Irene Gottlob; Frank Antony Proudlock
Journal:  Curr Neurol Neurosci Rep       Date:  2012-06       Impact factor: 5.081

2.  Effects of augmented tenotomy and reattachment in the infantile nystagmus syndrome.

Authors:  Louis F Dell'Osso; Faruk H Orge; Jonathan B Jacobs
Journal:  Digit J Ophthalmol       Date:  2016-03-31

3.  Eye muscle surgery for infantile nystagmus syndrome in the first two years of life.

Authors:  Richard W Hertle; Joost Felius; Dongsheng Yang; Matthew Kaufman
Journal:  Clin Ophthalmol       Date:  2009-11-16

4.  Effects of acetazolamide on infantile nystagmus syndrome waveforms: comparisons to contact lenses and convergence in a well-studied subject.

Authors:  M J Thurtell; L F Dell'osso; R J Leigh; M Matta; J B Jacobs; R L Tomsak
Journal:  Open Ophthalmol J       Date:  2010-07-29

5.  Oculomotor neurocircuitry, a structural connectivity study of infantile nystagmus syndrome.

Authors:  Nasser H Kashou; Angelica R Zampini
Journal:  PLoS One       Date:  2015-04-10       Impact factor: 3.240

6.  Clinical and electrophysiological results of eye muscle surgery in 17 patients with downbeat nystagmus.

Authors:  Richard W Hertle; Ashraf Ahmad
Journal:  Indian J Ophthalmol       Date:  2019-01       Impact factor: 1.848

  6 in total

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