| Literature DB >> 17280841 |
Gisa Gerold1, Arturo Zychlinsky, Juana L de Diego.
Abstract
Innate immunity relies on signalling by Toll-like receptors (TLRs) to alert the immune system of the presence of invading bacteria. TLR activation leads to the release of cytokines that allow for effective innate and adaptive immune responses. However, the contribution of different TLRs depends on the site of the infection and the pathogen. This review will describe the involvement of TLRs in the development of three different bacterial infections as well as our current understanding of the role of TLRs during microbial pathogenesis.Entities:
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Year: 2007 PMID： 17280841 DOI： 10.1016/j.smim.2006.12.003
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130