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Literature DB >> 172803

Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells.

Abstract

Biochemical analysis of cultured fibroblasts obtained from human subjects with the autosomal dominant disorder familial hypercholesterolemia has led to the identification of a hitherto unrecognized cell-surface receptor for serum lipoproteins. This receptor plays a critical role in the physiologic regulation of cholesterol metabolism in human cells, and its absence leads to elevation of serum-cholesterol levels and severe atheroslerosis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1975 PMID： 172803 DOI： 10.1007/bf00625346

Source DB: PubMed Journal: Naturwissenschaften ISSN： 0028-1042

17 in total

Review 1. Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations.

Authors: M S Brown; J L Goldstein
Journal: Adv Intern Med Date: 1975

2. Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection.

Authors: J L Goldstein; M J Harrod; M S Brown
Journal: Am J Hum Genet Date: 1974-03 Impact factor: 11.025

3. Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man.

Authors: J L Goldstein; M S Brown
Journal: Trans Assoc Am Physicians Date: 1974

4. Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol.

Authors: M S Brown; J L Goldstein
Journal: J Biol Chem Date: 1974-11-25 Impact factor: 5.157

5. Studies in the metabolism of cholesterol in subjects with normal plasma cholesterol levels and in patients with essential hypercholesterolaemia.

Authors: B Lewis; N B Myant
Journal: Clin Sci Date: 1967-04 Impact factor: 6.124

6. An evaluation of four methods for measuring cholesterol absorption by the intestine in man.

Authors: E Quintão; S M Grundy; E H Ahrens
Journal: J Lipid Res Date: 1971-03 Impact factor: 5.922

7. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.

Authors: J L Goldstein; W R Hazzard; H G Schrott; E L Bierman; A G Motulsky
Journal: J Clin Invest Date: 1973-07 Impact factor: 14.808

8. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

Authors: M S Brown; S E Dana; J L Goldstein
Journal: J Biol Chem Date: 1974-02-10 Impact factor: 5.157

Lipoprotein receptors and genetic control of cholesterol metabolism in cultured human cells.

Review 1. Familial hypercholesterolemia: genetic, biochemical and pathophysiologic considerations.

2. Homozygous familial hypercholesterolemia: specificity of the biochemical defect in cultured cells and feasibility of prenatal detection.

3. Expression of the familial hypercholesterolemia gene in heterozygotes: model for a dominant disorder in man.

4. Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol.

5. Studies in the metabolism of cholesterol in subjects with normal plasma cholesterol levels and in patients with essential hypercholesterolaemia.

6. An evaluation of four methods for measuring cholesterol absorption by the intestine in man.

7. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction.

8. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.

9. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

10. Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.

Review 1. [Cell receptor defects as the cause of endocrine and metabolic diseases (author's transl)].

Review 2. Regulation of cholesterol metabolism in man and in other species.

Review 3. The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis.

4. The effect of feeding human milk and adapted milk formulae on serum lipid and lipoprotein levels in young infants.

5. Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.