Literature DB >> 17279819

Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit.

Simon P Foxon1, Clive Metcalfe, Harry Adams, Michelle Webb, Jim A Thomas.   

Abstract

Three new ruthenium(II) complexes containing the tris(1-pyrazolyl)methane (tpm) ligand have been prepared: [Ru(tpm)(L)(dppn)]n+ (where n = 1; L = Cl (5), n = 2; L = MeCN (6) and pyridine (7); dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine). Complex 6 was structurally characterized by single-crystal X-ray diffraction. Binding parameters of these complexes with calf thymus DNA are reported and compared to those obtained for a previously reported monocation, [RuCl(tpm)(dppz)]+. Binding studies with the dications and the synthetic oligonucleotides poly(dA).poly(dT) and poly(dG).poly(dC) have also been determined. Photophysical and electrochemical properties of 5-7 have been investigated and compared with their dipyridophenazine (dppz) analogues.

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Year:  2007        PMID： 17279819     DOI： 10.1021/ic0607134

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  8 in total

1.  Cyclometalated Ruthenium(II) Complexes Derived from α-Oligothiophenes as Highly Selective Cytotoxic or Photocytotoxic Agents.

Authors:  Goutam Ghosh; Katsuya L Colón; Anderson Fuller; Tariq Sainuddin; Evan Bradner; Julia McCain; Susan M A Monro; Huimin Yin; Marc W Hetu; Colin G Cameron; Sherri A McFarland
Journal:  Inorg Chem       Date:  2018-06-21       Impact factor: 5.165

2.  Synthesis, Characterization and Photobiological Studies of Ru(II) Dyads Derived from α-Oligothiophene Derivatives of 1,10-Phenanthroline.

Authors:  Susan Monro; Colin G Cameron; Xiaolin Zhu; Katsuya L Colón; Huimin Yin; Tariq Sainuddin; Marc Hetu; Mitch Pinto; Anderson Fuller; Leah Bennett; John Roque; Wenfang Sun; Sherri A McFarland
Journal:  Photochem Photobiol       Date:  2018-10-27       Impact factor: 3.421

3.  Bis[pyrrolyl Ru(ii)] triads: a new class of photosensitizers for metal-organic photodynamic therapy.

Authors:  Deborah A Smithen; Susan Monro; Mitch Pinto; John Roque; Roberto M Diaz-Rodriguez; Huimin Yin; Colin G Cameron; Alison Thompson; Sherri A McFarland
Journal:  Chem Sci       Date:  2020-10-06       Impact factor: 9.825

4.  Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands.

Authors:  Cynthia Griffith; Adam S Dayoub; Thamara Jaranatne; Nagham Alatrash; Ali Mohamedi; Kenneth Abayan; Zachary S Breitbach; Daniel W Armstrong; Frederick M MacDonnell
Journal:  Chem Sci       Date:  2017-03-08       Impact factor: 9.825

Review 5.  Ruthenium polypyridine complexes combined with oligonucleotides for bioanalysis: a review.

Authors:  Shuyu Zhang; Yubin Ding; Hui Wei
Journal:  Molecules       Date:  2014-08-11       Impact factor: 4.411

6.  Photochemical Resolution of a Thermally Inert Cyclometalated Ru(phbpy)(N-N)(Sulfoxide)+ Complex.

Authors:  Lucien N Lameijer; Corjan van de Griend; Samantha L Hopkins; Anne-Geert Volbeda; Sven H C Askes; Maxime A Siegler; Sylvestre Bonnet
Journal:  J Am Chem Soc       Date:  2018-12-26       Impact factor: 15.419

7.  Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis.

Authors:  Jakub Cervinka; Alberto Gobbo; Lorenzo Biancalana; Lenka Markova; Vojtech Novohradsky; Massimo Guelfi; Stefano Zacchini; Jana Kasparkova; Viktor Brabec; Fabio Marchetti
Journal:  J Med Chem       Date:  2022-08-01       Impact factor: 8.039

8.  Tris-[4-(di-methyl-amino)-pyridine][tris(pyra-zol-1-yl)methane]--ruthenium(II) bis-(hexa-fluorido-phosphate) diethyl ether monosolvate.

Authors:  Benjamin J Coe; James Raftery; Daniela Rusanova
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-09-21
  8 in total

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