Literature DB >> 17279257

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid.

Ian Paterson1, Nicola M Gardner.   

Abstract

A 22-membered macrocyclic discodermolide/dictyostatin hybrid has been designed and synthesised; biological evaluation against a range of human cancer cell lines revealed significant levels of growth inhibition.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17279257     DOI： 10.1039/b615122a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal:  Nat Prod Rep       Date:  2015-08       Impact factor: 13.423

Review 2.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

3.  Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatin.

Authors:  Wei Zhu; María Jiménez; Won-Hyuk Jung; Daniel P Camarco; Raghavan Balachandran; Andreas Vogt; Billy W Day; Dennis P Curran
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

4.  Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

Authors:  Ian Paterson; Guy J Naylor; Nicola M Gardner; Esther Guzmán; Amy E Wright
Journal:  Chem Asian J       Date:  2010-10-28

5.  Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers.

Authors:  Youseung Shin; Jean-Hugues Fournier; Arndt Brückner; Charitha Madiraju; Raghavan Balachandran; Brianne S Raccor; Michael C Edler; Ernest Hamel; Rachel P Sikorski; Andreas Vogt; Billy W Day; Dennis P Curran
Journal:  Tetrahedron       Date:  2007-08-27       Impact factor: 2.457

Review 6.  Natural products from the Lithistida: a review of the literature since 2000.

Authors:  Priscilla L Winder; Shirley A Pomponi; Amy E Wright
Journal:  Mar Drugs       Date:  2011-12-15       Impact factor: 6.085

7.  Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.

Authors:  Chiara Trigili; Isabel Barasoain; Pedro A Sánchez-Murcia; Katja Bargsten; Mariano Redondo-Horcajo; Aurora Nogales; Nicola M Gardner; Arndt Meyer; Guy J Naylor; Elena Gómez-Rubio; Federico Gago; Michel O Steinmetz; Ian Paterson; Andrea E Prota; J Fernando Díaz
Journal:  ACS Omega       Date:  2016-12-13
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.