Literature DB >> 17279252

Chemistry and biology of resorcylic acid lactones.

Nicolas Winssinger1, Sofia Barluenga.   

Abstract

While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

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Year:  2006        PMID： 17279252     DOI： 10.1039/b610344h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  37 in total

1.  Total synthesis of LL-Z1640-2 utilizing a late-stage intramolecular Nozaki-Hiyama-Kishi reaction.

Authors:  Christopher A Leclair; Matthew B Boxer; Craig J Thomas; David J Maloney
Journal:  Tetrahedron Lett       Date:  2010-12-29       Impact factor: 2.415

2.  Radicicol, a Novel Lead Compound against the Migratory-Stage Schistosomula of Schistosoma japonicum.

Authors:  Liangxiong Xu; Qiuli Liu; Qingren Zeng; Ping Wu; Quan Yu; Kongzhen Gu; Jinghua Xue; Xiaoyi Wei
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

3.  Two Remarkable Epimerizations Imperative for the Success of an Asymmetric Total Synthesis of (+)-Aigialospirol.

Authors:  Ruth Figueroa; John B Feltenberger; Christle C Guevarra; Richard P Hsung
Journal:  Sci China Chem       Date:  2011-01-01       Impact factor: 9.445

Review 4.  Developing irreversible inhibitors of the protein kinase cysteinome.

Authors:  Qingsong Liu; Yogesh Sabnis; Zheng Zhao; Tinghu Zhang; Sara J Buhrlage; Lyn H Jones; Nathanael S Gray
Journal:  Chem Biol       Date:  2013-02-21

5.  Kinase inhibition by deoxy analogues of the resorcylic lactone L-783277.

Authors:  Marc Liniger; Christian Neuhaus; Tatjana Hofmann; Luca Fransioli-Ignazio; Michel Jordi; Peter Drueckes; Jörg Trappe; Doriano Fabbro; Karl-Heinz Altmann
Journal:  ACS Med Chem Lett       Date:  2010-10-20       Impact factor: 4.345

Review 6.  Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.

Authors:  Jing Xu; Cheng-shi Jiang; Zai-long Zhang; Wen-quan Ma; Yue-wei Guo
Journal:  Acta Pharmacol Sin       Date:  2014-01-27       Impact factor: 6.150

Review 7.  Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery.

Authors:  Kenneth K Hallenbeck; David M Turner; Adam R Renslo; Michelle R Arkin
Journal:  Curr Top Med Chem       Date:  2017       Impact factor: 3.295

8.  Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.

Authors:  Shuso Takeda; Shunsuke Okajima; Hiroko Miyoshi; Kazutaka Yoshida; Yoshiko Okamoto; Tomoko Okada; Toshiaki Amamoto; Kazuhito Watanabe; Curtis J Omiecinski; Hironori Aramaki
Journal:  Toxicol Lett       Date:  2012-09-08       Impact factor: 4.372

9.  Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus.

Authors:  Yuquan Xu; Patricia Espinosa-Artiles; Vivien Schubert; Ya-ming Xu; Wei Zhang; Min Lin; A A Leslie Gunatilaka; Roderich Süssmuth; István Molnár
Journal:  Appl Environ Microbiol       Date:  2013-01-18       Impact factor: 4.792

10.  A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.

Authors:  Meng Wang; Hui Zhou; Monica Wirz; Yi Tang; Christopher N Boddy
Journal:  Biochemistry       Date:  2009-07-14       Impact factor: 3.162
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