| Literature DB >> 17278263 |
Felix Agbalika1, Jerome Larghero, Helene Esperou, Dominique Marais, Marie Robin, Elena Foïs, Régis Peffault de Latour, Eliane Gluckman, Vanderson Rocha, Marc Benbunan, Gerard Socié, Jean-Pierre Marolleau.
Abstract
The occurrence of post-transplant lymphoproliferative disorders (PTLDs) after allogeneic haematopoietic stem cell transplantation (allo-HSCT) represents a clinical problem. Pretransplant Epstein-Barr virus serological status and viral load was determined in 21 recipients and 28 control transplanted patients, with (+) and without (-) PTLD, respectively. Early-antigen immunoglobulin G (EA-IgG) was detected in 12/21 PTLD+ patients, but only 2/28 PTLD patients (P = 0.00023, Odds ratio = 17.42). High viral load was detected in peripheral blood mononuclear cells at PTLD diagnosis, independently of deleted LMP1. Detection of EA-IgG in allo-HSCT recipients pretransplantation might be considered as risk factor for PTLD development.Entities:
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Year: 2007 PMID： 17278263 DOI： 10.1111/j.1365-2141.2006.06420.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998