AIM: To investigate the effect of partial splenic embolization (PSE) on platelet values in liver cirrhosis patients with thrombocytopenia and to determine the effective embolization area for platelet values improvement. METHODS: Blood parameters and liver function indicators were measured on 10 liver cirrhosis patients (6 in Child-Pugh grade A and 4 in grade B) with thrombocytopenia (platelet values < 80 x 10(3)/microL) before embolization. Computed tomography scan was also needed in advance to acquire the splenic baseline. After 2 to 3 d, angiography and splenic embolization were performed. A second computed tomography scan was made to confirm the embolization area after 2 to 3 wk of embolization. The blood parameters of patients were also examined biweekly during the 1 year follow-up period. RESULTS: According to the computed tomography images after partial splenic embolization, we divided all patients into two groups: low (< 30%), and high (> or = 30%) embolization area groups. The platelet values were increased by 3 times compared to baseline levels after 2 wk of embolization in high embolization area group. In addition, there were significant differences in platelet values between low and high embolization area groups. GPT values decreased significantly in all patients after 2 wk of embolization. The improvement in platelet and GPT values still persisted until 1 year after PSE. In addition, 3 of 4 (75%) Child-Pugh grade B patients progressed to grade A after 2 mo of PSE. The complication rate in < 30% and > or = 30% embolization area groups was 50% and 100%, respectively. CONCLUSION: Partial splenic embolization is an effective method to improve platelet values and GPT values in liver cirrhosis patients with thrombocytopenia and the > or = 30% embolization area is meaningful for platelet values improvement. The relationship between the complication rate and embolization area needs further studies.
AIM: To investigate the effect of partial splenic embolization (PSE) on platelet values in liver cirrhosispatients with thrombocytopenia and to determine the effective embolization area for platelet values improvement. METHODS: Blood parameters and liver function indicators were measured on 10 liver cirrhosispatients (6 in Child-Pugh grade A and 4 in grade B) with thrombocytopenia (platelet values < 80 x 10(3)/microL) before embolization. Computed tomography scan was also needed in advance to acquire the splenic baseline. After 2 to 3 d, angiography and splenic embolization were performed. A second computed tomography scan was made to confirm the embolization area after 2 to 3 wk of embolization. The blood parameters of patients were also examined biweekly during the 1 year follow-up period. RESULTS: According to the computed tomography images after partial splenic embolization, we divided all patients into two groups: low (< 30%), and high (> or = 30%) embolization area groups. The platelet values were increased by 3 times compared to baseline levels after 2 wk of embolization in high embolization area group. In addition, there were significant differences in platelet values between low and high embolization area groups. GPT values decreased significantly in all patients after 2 wk of embolization. The improvement in platelet and GPT values still persisted until 1 year after PSE. In addition, 3 of 4 (75%) Child-Pugh grade B patients progressed to grade A after 2 mo of PSE. The complication rate in < 30% and > or = 30% embolization area groups was 50% and 100%, respectively. CONCLUSION: Partial splenic embolization is an effective method to improve platelet values and GPT values in liver cirrhosispatients with thrombocytopenia and the > or = 30% embolization area is meaningful for platelet values improvement. The relationship between the complication rate and embolization area needs further studies.
Authors: Justyna Stanisławska; Bozenna Interewicz; Michal Maksymowicz; Maria Moscicka; Waldemar L Olszewski Journal: Ann Transplant Date: 2005 Impact factor: 1.530
Authors: B Sangro; I Bilbao; I Herrero; C Corella; J Longo; O Beloqui; J Ruiz; J M Zozaya; J Quiroga; J Prieto Journal: Hepatology Date: 1993-08 Impact factor: 17.425
Authors: M Miyazaki; H Itoh; T Kaiho; S Ohtawa; S Ambiru; S Hayashi; N Nakajima; H Oh; T Asai; T Iseki Journal: AJR Am J Roentgenol Date: 1994-07 Impact factor: 3.959
Authors: B Wernick; A Cipriano; S R Odom; U MacBean; R N Mubang; T R Wojda; S Liu; S Serres; D C Evans; P G Thomas; C H Cook; S P Stawicki Journal: Eur J Trauma Emerg Surg Date: 2016-05-11 Impact factor: 3.693