Literature DB >> 17277955

[Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion].

C Zimmer1, K Piepenbrink, G Riest, J Peters.   

Abstract

Accidental intravascular administration of bupivacaine can cause severe neurotoxic and cardiotoxic effects. We report a case of suspected bupivacaine intoxication due to intravascular injection via an epidural catheter and treatment with lidocaine, propofol, and a 20% lipid emulsion resulting in fast resolution of cardiotoxic and neurotoxic effects. Possible mechanisms of action of the medications used are discussed.

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Year:  2007        PMID： 17277955     DOI： 10.1007/s00101-007-1147-3

Source DB:  PubMed          Journal:  Anaesthesist        ISSN： 0003-2417            Impact factor:   1.041


  15 in total

1.  Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy.

Authors:  Guy Weinberg
Journal:  Anesthesiology       Date:  2006-07       Impact factor: 7.892

2.  The effect of age on systemic absorption and systemic disposition of bupivacaine after subarachnoid administration.

Authors:  B T Veering; A G Burm; A A Vletter; R A van den Hoeven; J Spierdijk
Journal:  Anesthesiology       Date:  1991-02       Impact factor: 7.892

3.  Serious complications related to regional anesthesia: results of a prospective survey in France.

Authors:  Y Auroy; P Narchi; A Messiah; L Litt; B Rouvier; K Samii
Journal:  Anesthesiology       Date:  1997-09       Impact factor: 7.892

4.  Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.

Authors:  K Knudsen; M Beckman Suurküla; S Blomberg; J Sjövall; N Edvardsson
Journal:  Br J Anaesth       Date:  1997-05       Impact factor: 9.166

5.  Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats.

Authors:  G L Weinberg; T VadeBoncouer; G A Ramaraju; M F Garcia-Amaro; M J Cwik
Journal:  Anesthesiology       Date:  1998-04       Impact factor: 7.892

6.  Cardiac electrophysiologic effects of lidocaine and bupivacaine.

Authors:  R A Moller; B G Covino
Journal:  Anesth Analg       Date:  1988-02       Impact factor: 5.108

7.  Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart.

Authors:  Guy L Weinberg; Richard Ripper; Patricia Murphy; Lucas B Edelman; William Hoffman; Gary Strichartz; Douglas L Feinstein
Journal:  Reg Anesth Pain Med       Date:  2006 Jul-Aug       Impact factor: 6.288

8.  Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole.

Authors:  C W Clarkson; L M Hondeghem
Journal:  Anesthesiology       Date:  1985-04       Impact factor: 7.892

9.  Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity.

Authors:  Guy Weinberg; Richard Ripper; Douglas L Feinstein; William Hoffman
Journal:  Reg Anesth Pain Med       Date:  2003 May-Jun       Impact factor: 6.288

10.  Comparison of propofol with thiopentone for treatment of bupivacaine-induced seizures in rats.

Authors:  J E Heavner; J Arthur; J Zou; K McDaniel; B Tyman-Szram; P H Rosenberg
Journal:  Br J Anaesth       Date:  1993-11       Impact factor: 9.166
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  10 in total

1.  [Accidental intravascular bupivacaine administration].

Authors:  S N Stehr; R J Litz; G L Weinberg
Journal:  Anaesthesist       Date:  2008-01       Impact factor: 1.041

Review 2.  [Lipid emulsion therapy for local anaesthetic toxicity. (LipidRescue)].

Authors:  K Ott
Journal:  Anaesthesist       Date:  2010-06       Impact factor: 1.041

3.  Prolonged duration local anesthesia with minimal toxicity.

Authors:  Hila Epstein-Barash; Iris Shichor; Albert H Kwon; Sherwood Hall; Michael W Lawlor; Robert Langer; Daniel S Kohane
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-13       Impact factor: 11.205

4.  Local toxicity from local anesthetic polymeric microparticles.

Authors:  J Brian McAlvin; Gally Reznor; Sahadev A Shankarappa; Cristina F Stefanescu; Daniel S Kohane
Journal:  Anesth Analg       Date:  2013-03-04       Impact factor: 5.108

5.  Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity.

Authors:  Ameneh Ghadiri; Leila Etemad; Mohammad Moshiri; Seyed Adel Moallem; Amir Hossein Jafarian; Farzin Hadizadeh; Mahmoud Seifi
Journal:  Iran J Basic Med Sci       Date:  2017-02       Impact factor: 2.699

Review 6.  Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.

Authors:  Seong-Ho Ok; Jeong-Min Hong; Soo Hee Lee; Ju-Tae Sohn
Journal:  Int J Med Sci       Date:  2018-05-14       Impact factor: 3.738

Review 7.  Local anesthetic toxicity: acute and chronic management.

Authors:  Kenichi Sekimoto; Masaru Tobe; Shigeru Saito
Journal:  Acute Med Surg       Date:  2017-03-06

8.  Linoleic Acid Attenuates the Toxic Dose of Bupivacaine-Mediated Reduction of Vasodilation Evoked by the Activation of Adenosine Triphosphate-Sensitive Potassium Channels.

Authors:  Soo Hee Lee; Dawon Kang; Seong-Ho Ok; Seong-Chun Kwon; Hyun-Jin Kim; Eun-Jin Kim; Jeong-Min Hong; Ji-Yoon Kim; Sung Il Bae; Seungmin An; Ju-Tae Sohn
Journal:  Int J Mol Sci       Date:  2018-06-26       Impact factor: 5.923

9.  Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta.

Authors:  Seong-Ho Ok; Jeong Yeol Han; Soo Hee Lee; Il-Woo Shin; Heon Keun Lee; Young-Kyun Chung; Mun-Jeoung Choi; Ju-Tae Sohn
Journal:  Korean J Anesthesiol       Date:  2013-04-22

10.  Lipofundin MCT/LCT Inhibits Levcromakalim-Induced Vasodilation by Inhibiting Endothelial Nitric Oxide Release.

Authors:  Soo Hee Lee; Dawon Kang; Seong-Ho Ok; Ji-Yoon Kim; Sung Il Bae; Yeran Hwang; Kyeong-Eon Park; Jong Won Kim; Ju-Tae Sohn
Journal:  Int J Mol Sci       Date:  2020-03-04       Impact factor: 5.923
  10 in total

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