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Literature DB >> 172778

The effect of triiodothyronine on myocardial protein kinases.

Abstract

Rats treated with T3 (triiodothyronine) showed an increased heart weight after 3 days reaching 100% after 3 weeks of treatment compared to untreated controls. Cytosol protein kinases were not significantly different in the T3 treated rats compared to controls. The protein kinase activity of the NHP (nonhistone proteins) increased after 2 hours and doubled after 3 days for each substrate tested. After 1 week of T3 treatment the protein kinase activity returned to the control value and remained at the control level for the remainder of the 3 week experimental period. A study of the distribution of protein kinase activity in the NHP by disc gel electrophoresis showed that there was a difference in the distribution of some peaks in the T3 treated animals compared to the controls. T3 in concentrations from 10(-11) to 10(-3) M had no in vitro effect on the phosvitin kinase activity of NHP and of cytosol.

Entities: Chemical Species

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Year: 1975 PMID： 172778 DOI： 10.1007/bf01732199

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

14 in total

1. Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.

Authors: H M KALCKAR
Journal: J Biol Chem Date: 1947-02 Impact factor: 5.157

2. Multiple forms of protein kinase in liver cell. I. Cytosol.

Authors: B Dastugue; L Tichonicky; J Kruh
Journal: Biochimie Date: 1973 Impact factor: 4.079

3. Studies of nuclear acidic proteins. Evidence for their phosphorylation, tissue specificity, selective binding to deoxyribonucleic acid, and stimulation effects on transcription.

Authors: C S Teng; C T Teng; V G Allfrey
Journal: J Biol Chem Date: 1971-06-10 Impact factor: 5.157

The effect of triiodothyronine on myocardial protein kinases.

1. Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism.

2. Multiple forms of protein kinase in liver cell. I. Cytosol.

3. Studies of nuclear acidic proteins. Evidence for their phosphorylation, tissue specificity, selective binding to deoxyribonucleic acid, and stimulation effects on transcription.

4. Multiple forms of protein kinase in liver cell. II. Nuclear kinases and cytosol phosvitin kinase.

5. Liver chromatin non-histone proteins. Partial fractionation and mechanism of action on RNA synthesis.

6. Estimation of molecular radius, free mobility, and valence using polyacylamide gel electrophoresis.

7. Phosphoproteins from calf-thymus nuclei: studies on the method of isolation.

8. Role of the receptor in the mechanism of action of adenosine 3':5'-cyclic monophosphate.

9. The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly.

10. Histone phosphokinase activity in nuclear and cytoplasmic cell fractions from normal and regenerating rat livers.

1. Nuclear receptors for thyroid hormone.