Literature DB >> 17277170

Drosophila melanogaster Thor and response to Candida albicans infection.

A Levitin1, A Marcil, G Tettweiler, M J Laforest, U Oberholzer, A M Alarco, D Y Thomas, P Lasko, M Whiteway.   

Abstract

We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BP(null) mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.

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Year:  2007        PMID： 17277170      PMCID： PMC1865646          DOI： 10.1128/EC.00346-06

Source DB:  PubMed          Journal:  Eukaryot Cell        ISSN： 1535-9786


  33 in total

1.  Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.

Authors:  André Nantel; Daniel Dignard; Catherine Bachewich; Doreen Harcus; Anne Marcil; Anne-Pascale Bouin; Christoph W Sensen; Hervé Hogues; Marco van het Hoog; Paul Gordon; Tracey Rigby; François Benoit; Daniel C Tessier; David Y Thomas; Malcolm Whiteway
Journal:  Mol Biol Cell       Date:  2002-10       Impact factor: 4.138

Review 2.  Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.

Authors:  M J Clemens
Journal:  J Cell Mol Med       Date:  2001 Jul-Sep       Impact factor: 5.310

Review 3.  Drosophila blood cells.

Authors:  Marie Meister; Marie Lagueux
Journal:  Cell Microbiol       Date:  2003-09       Impact factor: 3.715

4.  Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila.

Authors:  Alan M Pearson; Katalin Baksa; Mika Rämet; Meredith Protas; Mary McKee; Dennis Brown; R Alan B Ezekowitz
Journal:  Microbes Infect       Date:  2003-08       Impact factor: 2.700

5.  Localisation and regulation of the eIF4E-binding protein 4E-BP3.

Authors:  Miranda Kleijn; Gert C Scheper; Mary L Wilson; Andrew R Tee; Christopher G Proud
Journal:  FEBS Lett       Date:  2002-12-18       Impact factor: 4.124

6.  Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.

Authors:  Juan José Berlanga; Alexis Baass; Nahum Sonenberg
Journal:  RNA       Date:  2006-06-27       Impact factor: 4.942

7.  Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli.

Authors:  Mika Rämet; Pascal Manfruelli; Alan Pearson; Bernard Mathey-Prevot; R Alan B Ezekowitz
Journal:  Nature       Date:  2002-03-24       Impact factor: 49.962

8.  Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans.

Authors:  C R Rocha; K Schröppel; D Harcus; A Marcil; D Dignard; B N Taylor; D Y Thomas; M Whiteway; E Leberer
Journal:  Mol Biol Cell       Date:  2001-11       Impact factor: 4.138

9.  Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity.

Authors:  A Bernal; D A Kimbrell
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

10.  Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.

Authors:  Oscar Puig; Michael T Marr; M Laure Ruhf; Robert Tjian
Journal:  Genes Dev       Date:  2003-07-31       Impact factor: 11.361
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  11 in total

1.  The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection.

Authors:  Deepika Vasudevan; Nicholas K Clark; Jessica Sam; Victoria C Cotham; Beatrix Ueberheide; Michael T Marr; Hyung Don Ryoo
Journal:  Cell Rep       Date:  2017-11-21       Impact factor: 9.423

2.  Identification of methylmercury tolerance gene candidates in Drosophila.

Authors:  Cecon T Mahapatra; Jeffrey Bond; David M Rand; Matthew D Rand
Journal:  Toxicol Sci       Date:  2010-04-07       Impact factor: 4.849

3.  Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila.

Authors:  Aurélien Lauwers; Laure Twyffels; Romuald Soin; Corinne Wauquier; Véronique Kruys; Cyril Gueydan
Journal:  J Biol Chem       Date:  2009-01-28       Impact factor: 5.157

4.  Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis.

Authors:  Georgios Chamilos; Russell E Lewis; Jianhua Hu; Lianchun Xiao; Tomasz Zal; Michel Gilliet; Georg Halder; Dimitrios P Kontoyiannis
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-26       Impact factor: 11.205

5.  Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions.

Authors:  A Marcil; C Gadoury; J Ash; J Zhang; A Nantel; M Whiteway
Journal:  Infect Immun       Date:  2008-07-14       Impact factor: 3.441

6.  The Drosophila melanogaster host model.

Authors:  Christina O Igboin; Ann L Griffen; Eugene J Leys
Journal:  J Oral Microbiol       Date:  2012-02-21       Impact factor: 5.474

7.  Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.

Authors:  Monica M Davis; Francisco J Alvarez; Kicki Ryman; Åsa A Holm; Per O Ljungdahl; Ylva Engström
Journal:  PLoS One       Date:  2011-11-14       Impact factor: 3.240

8.  Recent Advances in the Use of Drosophila melanogaster as a Model to Study Immunopathogenesis of Medically Important Filamentous Fungi.

Authors:  Georgios Hamilos; George Samonis; Dimitrios P Kontoyiannis
Journal:  Int J Microbiol       Date:  2012-02-19

9.  A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection.

Authors:  Marcus T Glittenberg; Ilias Kounatidis; Magda Atilano; Petros Ligoxygakis
Journal:  Dis Model Mech       Date:  2022-05-09       Impact factor: 5.732

10.  EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection.

Authors:  Marc Swidergall; Norma V Solis; Zeping Wang; Quynh T Phan; Michaela E Marshall; Michail S Lionakis; Eric Pearlman; Scott G Filler
Journal:  Cell Rep       Date:  2019-07-09       Impact factor: 9.423
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