| Literature DB >> 17276687 |
Cristina Martins1, Mekala Gunaratnam, John Stuart, Vaidahi Makwana, Olga Greciano, Anthony P Reszka, Lloyd R Kelland, Stephen Neidle.
Abstract
The design, synthesis, biophysical and biochemical evaluation is presented of a new series of benzylamino-substituted acridines as G-quadruplex binding telomerase inhibitors. Replacement of the previously reported anilino substituents by benzylamino groups results in enhanced quadruplex interaction, and for one compound, superior telomerase inhibitory activity.Entities:
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Year: 2007 PMID： 17276687 DOI： 10.1016/j.bmcl.2007.01.056
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823