| Literature DB >> 17276686 |
Muriel Lalanne1, Angelo Paci, Karine Andrieux, Nathalie Dereuddre-Bosquet, Pascal Clayette, Alain Deroussent, Micheline Ré, Gilles Vassal, Patrick Couvreur, Didier Desmaële.
Abstract
Novel glycerolipidic prodrugs of didanosine and didanosine monophosphate designed to by-pass the hepatic first pass metabolism were synthesized and tested for their cytotoxicity and anti-HIV-1 activity. Formulation as liposomes of dipalmitoylphosphatidylcholine was elaborated. A simple quantitative HPLC-UV method was developed and validated, and ESI-MS was used for qualitative purpose. These two prodrugs exhibited promising biological activities against HIV-1 in in vitro infected cell culture.Entities:
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Year: 2007 PMID： 17276686 DOI： 10.1016/j.bmcl.2007.01.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823