| Literature DB >> 17276680 |
Fedra M Leonik1, Roger L Papke, Nicole A Horenstein.
Abstract
The alpha7 subtype of the neuronal nicotinic acetylcholine receptors (nAChRs) was targeted for the design of selective agonists deriving from the quinuclidine scaffold. Arylidene groups at the 3-position and N-methyl quinuclidine were found to be selective agonists with EC(50)s of 1.5 and 40 microM, respectively.Entities:
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Year: 2007 PMID： 17276680 DOI： 10.1016/j.bmcl.2007.01.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823