Literature DB >> 17276588

Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell.

Rina Ohashi1, Fumiyuki Takahashi, Ri Cui, Masakata Yoshioka, Tao Gu, Shinichi Sasaki, Shigeru Tominaga, Kazuto Nishio, Kenneth K Tanabe, Kazuhisa Takahashi.   

Abstract

CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism.

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Year:  2007        PMID： 17276588     DOI： 10.1016/j.canlet.2006.12.025

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  39 in total

1.  CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor β1 and tumor necrosis factor α in lung cancer: Preliminary findings.

Authors:  Fariz Nurwidya; Fumiyuki Takahashi; Motoyasu Kato; Hario Baskoro; Moulid Hidayat; Aditya Wirawan; Kazuhisa Takahashi
Journal:  Bosn J Basic Med Sci       Date:  2017-08-20       Impact factor: 3.363

2.  Cancer spheres from gastric cancer patients provide an ideal model system for cancer stem cell research.

Authors:  Myoung-Eun Han; Tae-Yong Jeon; Sun-Hwi Hwang; Young-Suk Lee; Hyun-Jung Kim; Hye-Eun Shim; Sik Yoon; Sun-Yong Baek; Bong-Seon Kim; Chi-Dug Kang; Sae-Ock Oh
Journal:  Cell Mol Life Sci       Date:  2011-03-30       Impact factor: 9.261

3.  Spatially graded hydrogels for preclinical testing of glioblastoma anticancer therapeutics.

Authors:  S Pedron; H Polishetty; A M Pritchard; B P Mahadik; J N Sarkaria; B A C Harley
Journal:  MRS Commun       Date:  2017-09-12       Impact factor: 2.566

4.  Lack of association between expression of MRP2 and early relapse of colorectal cancer in patients receiving FOLFOX-4 chemotherapy.

Authors:  Mojgan Mirakhorli; Nasrin Shayanfar; Sabariah Abdul Rahman; Rozita Rosli; Syahrilnizam Abdullah; Ahad Khoshzaban
Journal:  Oncol Lett       Date:  2012-08-31       Impact factor: 2.967

5.  Effects of Lewis Y antigen on the gene expression of multiple drug resistance-associated proteins in human ovarian cancer RMG-I-H cells.

Authors:  Song Gao; Qing Liu; Xinyan Wang; Bei Lin; Shulan Zhang
Journal:  Med Oncol       Date:  2009-09-23       Impact factor: 3.064

6.  Cytokines and growth factors stimulate hyaluronan production: role of hyaluronan in epithelial to mesenchymal-like transition in non-small cell lung cancer.

Authors:  Geraldine Chow; Jordi Tauler; James L Mulshine
Journal:  J Biomed Biotechnol       Date:  2010-06-30

7.  Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.

Authors:  Lilly Y W Bourguignon; Weiliang Xia; Gabriel Wong
Journal:  J Biol Chem       Date:  2008-12-01       Impact factor: 5.157

Review 8.  Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells.

Authors:  Bryan P Toole; Mark G Slomiany
Journal:  Semin Cancer Biol       Date:  2008-03-26       Impact factor: 15.707

9.  Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.

Authors:  Lilly Y W Bourguignon; Christina C Spevak; Gabriel Wong; Weiliang Xia; Eli Gilad
Journal:  J Biol Chem       Date:  2009-07-24       Impact factor: 5.157

10.  Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells.

Authors:  Lilly Y W Bourguignon; Karine Peyrollier; Weiliang Xia; Eli Gilad
Journal:  J Biol Chem       Date:  2008-04-25       Impact factor: 5.157
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