Literature DB >> 17276351

How do I fatten thee? Let me count the ways...

Rosalind A Coleman1.   

Abstract

Glycerol-3-phosphate acyltransferase (GPAT) initiates the synthesis of triacylglycerol and phospholipids and, in the process, regulates the formation of several lipid metabolites known to be intracellular signaling molecules. The recent identification of a new GPAT isoform (Cao et al., 2006) suggests a role for GPAT isoforms in nutrient-mediated signaling.

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Year:  2007        PMID： 17276351      PMCID： PMC2819350          DOI： 10.1016/j.cmet.2007.01.004

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  11 in total

Review 1.  Enzymes of triacylglycerol synthesis and their regulation.

Authors:  Rosalind A Coleman; Douglas P Lee
Journal:  Prog Lipid Res       Date:  2004-03       Impact factor: 16.195

2.  Metabolism of lipides.

Authors:  E P KENNEDY
Journal:  Annu Rev Biochem       Date:  1957       Impact factor: 23.643

3.  Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase.

Authors:  D H Shin; J D Paulauskis; N Moustaïd; H S Sul
Journal:  J Biol Chem       Date:  1991-12-15       Impact factor: 5.157

4.  Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition.

Authors:  Linda E Hammond; Patricia A Gallagher; Shuli Wang; Sylvia Hiller; Kimberly D Kluckman; Eugenia L Posey-Marcos; Nobuyo Maeda; Rosalind A Coleman
Journal:  Mol Cell Biol       Date:  2002-12       Impact factor: 4.272

5.  Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis.

Authors:  Jingsong Cao; Jian-Liang Li; Dongmei Li; James F Tobin; Ruth E Gimeno
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-14       Impact factor: 11.205

Review 6.  Etiology of insulin resistance.

Authors:  Kitt Falk Petersen; Gerald I Shulman
Journal:  Am J Med       Date:  2006-05       Impact factor: 4.965

7.  Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.

Authors:  Anne P Beigneux; Laurent Vergnes; Xin Qiao; Steven Quatela; Ryan Davis; Steven M Watkins; Rosalind A Coleman; Rosemary L Walzem; Mark Philips; Karen Reue; Stephen G Young
Journal:  J Lipid Res       Date:  2006-01-31       Impact factor: 5.922

Review 8.  Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action.

Authors:  Maria R Gonzalez-Baró; Tal M Lewin; Rosalind A Coleman
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2006-12-07       Impact factor: 4.052

9.  Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.

Authors:  Linda E Hammond; Susanne Neschen; Anthony J Romanelli; Gary W Cline; Olga R Ilkayeva; Gerald I Shulman; Deborah M Muoio; Rosalind A Coleman
Journal:  J Biol Chem       Date:  2005-05-06       Impact factor: 5.157

10.  Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria.

Authors:  Tal M Lewin; Nicole M J Schwerbrock; Douglas P Lee; Rosalind A Coleman
Journal:  J Biol Chem       Date:  2004-01-14       Impact factor: 5.157
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  9 in total

1.  Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.

Authors:  Chongben Zhang; Angela A Wendel; Matthew R Keogh; Thurl E Harris; Jie Chen; Rosalind A Coleman
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

2.  The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding.

Authors:  William J Brown; Helen Plutner; Daniel Drecktrah; Bret L Judson; William E Balch
Journal:  Traffic       Date:  2008-03-04       Impact factor: 6.215

3.  Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

Authors:  Zhouji Chen; Matthew C Gropler; Jin Norris; John C Lawrence; Thurl E Harris; Brian N Finck
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-07-31       Impact factor: 8.311

4.  Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice.

Authors:  Cynthia A Nagle; Laurent Vergnes; Hendrik Dejong; Shuli Wang; Tal M Lewin; Karen Reue; Rosalind A Coleman
Journal:  J Lipid Res       Date:  2008-01-11       Impact factor: 5.922

5.  Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.

Authors:  Manju Kumari; Gabriele Schoiswohl; Chandramohan Chitraju; Margret Paar; Irina Cornaciu; Ashraf Y Rangrez; Nuttaporn Wongsiriroj; Harald M Nagy; Pavlina T Ivanova; Sarah A Scott; Oskar Knittelfelder; Gerald N Rechberger; Ruth Birner-Gruenberger; Sandra Eder; H Alex Brown; Guenter Haemmerle; Monika Oberer; Achim Lass; Erin E Kershaw; Robert Zimmermann; Rudolf Zechner
Journal:  Cell Metab       Date:  2012-05-02       Impact factor: 27.287

6.  Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.

Authors:  Martin W Bratschi; David P Burrowes; Adam Kulaga; Jing F Cheung; Ana L Alvarez; Jennifer Kearley; Vanina Zaremberg
Journal:  Eukaryot Cell       Date:  2009-06-12

Review 7.  Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity.

Authors:  Regina F Fernandez; Jessica M Ellis
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2020-09-15       Impact factor: 4.006

8.  Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation.

Authors:  Nancy Marr; Julena Foglia; Mauricio Terebiznik; Karin Athenstaedt; Vanina Zaremberg
Journal:  J Biol Chem       Date:  2012-01-21       Impact factor: 5.157

9.  Phylogenetic analysis of glycerol 3-phosphate acyltransferases in opisthokonts reveals unexpected ancestral complexity and novel modern biosynthetic components.

Authors:  Heather C Smart; Fred D Mast; Maxwell F J Chilije; Marjan Tavassoli; Joel B Dacks; Vanina Zaremberg
Journal:  PLoS One       Date:  2014-10-23       Impact factor: 3.240
  9 in total

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