T A Hassen1, S Pearson, P A Cowled, R A Fitridge. 1. Discipline of Surgery, School of Medicine, The University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia.
Abstract
OBJECTIVES: This study examined the relationship between pre-operative nutritional status and systemic inflammatory response syndrome (SIRS) or sepsis following major vascular surgery. DESIGN AND METHODS: Subjects undergoing open AAA repair, EVAR or lower limb revascularisation were studied prospectively. Pre-operative nutrition was assessed clinically using Mini-Nutritional Assessment (MNA) and body composition was measured by dual energy X-ray absorptiometry (DEXA) scanning. SIRS severity was assessed for 5 post-operative days and sepsis noted within 30 days of surgery. RESULTS: Using MNA, neither SIRS severity nor sepsis occurrence differed significantly between 'well-nourished' subjects and those 'at risk of malnutrition'. Using DEXA, negative associations existed between body mass index and both SIRS score and SIRS duration. Fat free mass (FFM) was negatively associated with SIRS score and duration. Negative associations also existed between skeletal muscle mass (SMM) and SIRS score and duration. SMM was also negatively correlated with post-operative length of stay in hospital. There were no significant correlations between sepsis and any nutritional indices. CONCLUSIONS: Lower pre-operative nutritional indices, indicating protein energy malnutrition, were associated with more severe systemic inflammatory responses following major vascular surgery.
OBJECTIVES: This study examined the relationship between pre-operative nutritional status and systemic inflammatory response syndrome (SIRS) or sepsis following major vascular surgery. DESIGN AND METHODS: Subjects undergoing open AAA repair, EVAR or lower limb revascularisation were studied prospectively. Pre-operative nutrition was assessed clinically using Mini-Nutritional Assessment (MNA) and body composition was measured by dual energy X-ray absorptiometry (DEXA) scanning. SIRS severity was assessed for 5 post-operative days and sepsis noted within 30 days of surgery. RESULTS: Using MNA, neither SIRS severity nor sepsis occurrence differed significantly between 'well-nourished' subjects and those 'at risk of malnutrition'. Using DEXA, negative associations existed between body mass index and both SIRS score and SIRS duration. Fat free mass (FFM) was negatively associated with SIRS score and duration. Negative associations also existed between skeletal muscle mass (SMM) and SIRS score and duration. SMM was also negatively correlated with post-operative length of stay in hospital. There were no significant correlations between sepsis and any nutritional indices. CONCLUSIONS: Lower pre-operative nutritional indices, indicating protein energy malnutrition, were associated with more severe systemic inflammatory responses following major vascular surgery.
Authors: Cassius Iyad Ochoa Chaar; Tamara N Fitzgerald; Michael Dewan; Matthew Huddle; Felix J Schlosser; Melissa Perkal; Bart E Muhs; Alan Dardik Journal: Am J Surg Date: 2009-11 Impact factor: 2.565
Authors: E B Haverkort; P L M Reijven; J M Binnekade; M A E de van der Schueren; C P Earthman; D J Gouma; R J de Haan Journal: Eur J Clin Nutr Date: 2014-10-01 Impact factor: 4.016
Authors: Lorenzo Maria Donini; Barbara Neri; Stefania De Chiara; Eleonora Poggiogalle; Maurizio Muscaritoli Journal: PLoS One Date: 2013-02-06 Impact factor: 3.240
Authors: Lorenzo M Donini; Blossom C M Stephan; Aldo Rosano; Alessio Molfino; Eleonora Poggiogalle; Andrea Lenzi; Mario Siervo; Maurizio Muscaritoli Journal: Nutrients Date: 2020-09-18 Impact factor: 5.717