BACKGROUND: Pulmonary arterial capacitance (PAC) has been associated with right ventricular (RV) workload and mortality in pulmonary hypertension, but is not routinely evaluated in children. We investigated whether PAC can be estimated noninvasively by echocardiography. METHODS: We retrospectively determined PAC in 31 children with pulmonary hypertension, using echocardiography, and compared the results with those obtained at cardiac catheterization. RESULTS: PAC derived from echocardiography was similar to that derived from catheterization (mean +/- SD 1.16 +/- 1.0 vs 1.10 +/- 0.95 mL(3) x mm Hg(-1), P = not significant) and the two correlated well (r = 0.74, P < .0001). There was a highly significant polynomial relationship between PAC and RV anterior wall thickness indexed to body surface area (R(2) = 0.54, P < .0001), but not between pulmonary vascular resistance and RV wall thickness. Pulmonary vascular resistance and PAC did not correlate. CONCLUSIONS: Echocardiography can reliably estimate PAC, which strongly correlates with RV hypertrophy, a surrogate for RV work.
BACKGROUND: Pulmonary arterial capacitance (PAC) has been associated with right ventricular (RV) workload and mortality in pulmonary hypertension, but is not routinely evaluated in children. We investigated whether PAC can be estimated noninvasively by echocardiography. METHODS: We retrospectively determined PAC in 31 children with pulmonary hypertension, using echocardiography, and compared the results with those obtained at cardiac catheterization. RESULTS:PAC derived from echocardiography was similar to that derived from catheterization (mean +/- SD 1.16 +/- 1.0 vs 1.10 +/- 0.95 mL(3) x mm Hg(-1), P = not significant) and the two correlated well (r = 0.74, P < .0001). There was a highly significant polynomial relationship between PAC and RV anterior wall thickness indexed to body surface area (R(2) = 0.54, P < .0001), but not between pulmonary vascular resistance and RV wall thickness. Pulmonary vascular resistance and PAC did not correlate. CONCLUSIONS: Echocardiography can reliably estimate PAC, which strongly correlates with RV hypertrophy, a surrogate for RV work.
Authors: Juan A Quintero-Martinez; Waldemar E Wysokinski; Sandra N Cordova-Madera; Renzo J Mogollon; Mariana Garcia-Arango; Danielle T Vlazny; Damon E Houghton; Ana I Casanegra; Hector R Villarraga Journal: Eur Heart J Open Date: 2022-02-23
Authors: Thomas S Metkus; Stephen C Mathai; Thorsten Leucker; Paul M Hassoun; Ryan J Tedford; Frederick K Korley Journal: Pulm Circ Date: 2020-07-23 Impact factor: 3.017
Authors: Thomas S Metkus; Emmanouil Tampakakis; Christopher J Mullin; Brian A Houston; Todd M Kolb; Stephen C Mathai; Rachel Damico; Bradley A Maron; Paul M Hassoun; Roy G Brower; Ryan J Tedford Journal: Crit Care Med Date: 2017-03 Impact factor: 7.598