OBJECTIVE: We sought to determine left atrial (LA) volume and systolic function (LA remodeling) in younger (<70 years) patients with systolic and diastolic heart failure (HF). METHODS: In all, 32 patients with diastolic HF (left ventricular [LV] ejection fraction > or = 0.50), 26 patients with systolic HF (LV ejection fraction < 0.50), and 48 control subjects were studied. LAlpha volume (cm(3)/m(2)) was echocardiographically determined at mitral valve opening (maximal), mitral valve closure (minimal), and atrial systole (electrocardiographic Rho wave) using the biplane area-length method. The LA active emptying fraction (%) and ejection force (kdyne/m(2)) served as indices of LA systolic function. RESULTS: LA maximal volume was greater in systolic HF than diastolic HF and in the latter greater than control (68.6 +/- 13.8 vs 52 +/- 11.6 vs 42.9 +/- 14.4, respectively, P < .0001). Active emptying fraction was similar between diastolic HF and control, and greater than systolic HF (31.5 +/- 8.1 vs 36.3 +/- 7 vs 26.6 +/- 6.2, respectively, P < .0001), whereas LA ejection force was similar in diastolic and systolic HF and greater than control (5.05 +/- 1.3 vs 4.98 +/- 2.17 vs 3.63 +/- 2.05, respectively, P = .001). Vmax was related to body surface area, brain natriuretic peptide, and LV mass in diastolic HF (multiple R2 = 0.74) and to diastolic blood pressure, LV mass, and early to late transmitral flow velocity ratio in systolic HF (multiple R2 = 0.96). CONCLUSIONS: LA remodeling is more severe in systolic HF than diastolic HF and governed by different mechanisms. This may be of significant clinical relevance regarding the morbidity and mortality of these two conditions.
OBJECTIVE: We sought to determine left atrial (LA) volume and systolic function (LA remodeling) in younger (<70 years) patients with systolic and diastolic heart failure (HF). METHODS: In all, 32 patients with diastolic HF (left ventricular [LV] ejection fraction > or = 0.50), 26 patients with systolic HF (LV ejection fraction < 0.50), and 48 control subjects were studied. LAlpha volume (cm(3)/m(2)) was echocardiographically determined at mitral valve opening (maximal), mitral valve closure (minimal), and atrial systole (electrocardiographic Rho wave) using the biplane area-length method. The LA active emptying fraction (%) and ejection force (kdyne/m(2)) served as indices of LA systolic function. RESULTS: LA maximal volume was greater in systolic HF than diastolic HF and in the latter greater than control (68.6 +/- 13.8 vs 52 +/- 11.6 vs 42.9 +/- 14.4, respectively, P < .0001). Active emptying fraction was similar between diastolic HF and control, and greater than systolic HF (31.5 +/- 8.1 vs 36.3 +/- 7 vs 26.6 +/- 6.2, respectively, P < .0001), whereas LA ejection force was similar in diastolic and systolic HF and greater than control (5.05 +/- 1.3 vs 4.98 +/- 2.17 vs 3.63 +/- 2.05, respectively, P = .001). Vmax was related to body surface area, brain natriuretic peptide, and LV mass in diastolic HF (multiple R2 = 0.74) and to diastolic blood pressure, LV mass, and early to late transmitral flow velocity ratio in systolic HF (multiple R2 = 0.96). CONCLUSIONS: LA remodeling is more severe in systolic HF than diastolic HF and governed by different mechanisms. This may be of significant clinical relevance regarding the morbidity and mortality of these two conditions.
Authors: Giovanni Cioffi; Eva Gerdts; Dana Cramariuc; Luigi Tarantini; Andrea Di Lenarda; Giovanni Pulignano; Donatella Del Sindaco; Carlo Stefenelli; Giovanni de Simone Journal: Exp Clin Cardiol Date: 2010