Yoshitaka Fujii1, Masahiro Nakayama. 1. Department of Anesthesiology; University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan. yfujii@med.toho-u.ac.jp
Abstract
OBJECTIVE: To evaluate the efficacy of dexamethasone for reducing postoperative nausea and vomiting (PONV) and analgesic requirements after thyroidectomy. STUDY DESIGN AND SETTING: In a prospective, randomized, double-blind, placebo-controlled study, 75 patients, 20 men and 55 women, received intravenously placebo or dexamethasone at 2 different doses (4 and 8 mg) (n=25 of each) at the end of surgery. A standard general anesthetic technique was used. PONV and analgesic requirements were evaluated. RESULTS: The rate of patients experiencing PONV during the first 24 hours after anesthesia was 64% with dexamethasone 4 mg (P=0.269) and 28% with dexamethasone 8 mg (P=0.001), compared with placebo (76%). The need of indomethacin for intolerable pain was less in patients who had received dexamethasone 8 mg than in those who had received placebo (P=0.009). CONCLUSION:Dexamethasone 8 mg effectively decreases PONV and analgesic requirements after thyroidectomy.
RCT Entities:
OBJECTIVE: To evaluate the efficacy of dexamethasone for reducing postoperative nausea and vomiting (PONV) and analgesic requirements after thyroidectomy. STUDY DESIGN AND SETTING: In a prospective, randomized, double-blind, placebo-controlled study, 75 patients, 20 men and 55 women, received intravenously placebo or dexamethasone at 2 different doses (4 and 8 mg) (n=25 of each) at the end of surgery. A standard general anesthetic technique was used. PONV and analgesic requirements were evaluated. RESULTS: The rate of patients experiencing PONV during the first 24 hours after anesthesia was 64% with dexamethasone 4 mg (P=0.269) and 28% with dexamethasone 8 mg (P=0.001), compared with placebo (76%). The need of indomethacin for intolerable pain was less in patients who had received dexamethasone 8 mg than in those who had received placebo (P=0.009). CONCLUSION:Dexamethasone 8 mg effectively decreases PONV and analgesic requirements after thyroidectomy.
Authors: B M Künzli; M Walensi; J Wilimsky; C Bucher; T Bührer; C Kull; A Zuse; C A Maurer Journal: Langenbecks Arch Surg Date: 2019-06-26 Impact factor: 3.445