| Literature DB >> 17275296 |
Shizuka Ban1, Hidehiko Nakagawa, Takayoshi Suzuki, Naoki Miyata.
Abstract
Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, and apoptosis, are thought to be associated with oxidative stress affecting mitochondria. In this study, we designed and synthesized a fluorescein-tagged TEMPO derivative, compound 1, with triphenylphosphino moiety. Synthesized 1 localized in mitochondria and detected oxidative stress in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress in mitochondria.Entities:
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Year: 2007 PMID： 17275296 DOI： 10.1016/j.bmcl.2007.01.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823