Literature DB >> 17275295

Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

Yi Bi1, Jinyi Xu, Xiaoming Wu, Wencai Ye, Shengtao Yuan, Luyong Zhang.   

Abstract

New 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives were prepared and tested for cytotoxic activity on five cancer cell lines in vitro: all tested compounds showed stronger cytotoxic activity than 23-hydroxy betulinic acid and betulinic acid. In addition, compound 5a was tested for anti-tumor activity in vivo: it had much better anti-tumor activity than 23-OH betulinic acid and had similar anti-tumor activity with cyclophosphamide and 5-fluorouracil.

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Year:  2006        PMID： 17275295     DOI： 10.1016/j.bmcl.2006.09.096

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Enhancement of the Antioxidant and Skin Permeation Properties of Betulin and Its Derivatives.

Authors:  Andrzej Günther; Edyta Makuch; Anna Nowak; Wiktoria Duchnik; Łukasz Kucharski; Robert Pełech; Adam Klimowicz
Journal:  Molecules       Date:  2021-06-05       Impact factor: 4.411

Review 2.  Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.

Authors:  Sulong Xiao; Zhenyu Tian; Yufei Wang; Longlong Si; Lihe Zhang; Demin Zhou
Journal:  Med Res Rev       Date:  2018-01-19       Impact factor: 12.944

3.  Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin.

Authors:  Elwira Chrobak; Maria Jastrzębska; Ewa Bębenek; Monika Kadela-Tomanek; Krzysztof Marciniec; Małgorzata Latocha; Roman Wrzalik; Joachim Kusz; Stanisław Boryczka
Journal:  Molecules       Date:  2021-01-31       Impact factor: 4.411

4.  Antioxidative-, Antimicrobial-, Enzyme Inhibition-, and Cytotoxicity-Based Fractionation and Isolation of Active Components from Monotheca buxifolia (Falc.) A. DC. Stem Extracts.

Authors:  Joham Sarfraz Ali; Naheed Riaz; Abdul Mannan; Saira Tabassum; Muhammad Zia
Journal:  ACS Omega       Date:  2022-01-18

5.  Betulinic Acid for cancer treatment and prevention.

Authors:  Simone Fulda
Journal:  Int J Mol Sci       Date:  2008-06-27       Impact factor: 6.208

6.  Betulin is a potent anti-tumor agent that is enhanced by cholesterol.

Authors:  Franziska B Mullauer; Jan H Kessler; Jan Paul Medema
Journal:  PLoS One       Date:  2009-04-28       Impact factor: 3.240

7.  Synthesis and biological activity of 23-hydroxybetulinic acid C-28 ester derivatives as antitumor agent candidates.

Authors:  Yi Bi; Jinyi Xu; Fei Sun; Xiaoming Wu; Wencai Ye; Yijun Sun; Wenwen Huang
Journal:  Molecules       Date:  2012-07-25       Impact factor: 4.411
  7 in total

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