| Literature DB >> 17275263 |
Carina Romanutti1, Viviana Castilla, Celia E Coto, Mónica B Wachsman.
Abstract
The antiviral mode of action of the synthetic brassinosteroid (22S,23S)-3beta-bromo-5alpha,22,23-trihydroxystigmastan-6-one (6b) against replication of vesicular stomatitis virus (VSV) in Vero cells was investigated. Time-related experiments showed that 6b mainly affects a late event of the virus growth cycle. Virus adsorption, internalisation and early RNA synthesis are not the target of the inhibitory action. Results obtained indicate that the antiviral compound adversely affects virus protein synthesis and viral mature particle formation.Entities:
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Year: 2007 PMID： 17275263 DOI： 10.1016/j.ijantimicag.2006.11.005
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283