| Literature DB >> 17275101 |
Andréa Alice Silva1, Ester Roffê, Helton Santiago, Ana Paula Marino, Karina Kroll-Palhares, Mauro Martins Teixeira, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira.
Abstract
Encephalitis rarely occurs during acute Trypanosoma cruzi infection. However, the central nervous system (CNS) is the major site of infection reactivation in immunocompromised patients. We show that the acute T. cruzi-triggered CD8-enriched meningoencephalitis paralleled the in situ expression of CCL3/MIP-1alpha and CCL5/RANTES mRNA. The frequency of CCR5-bearing cells was increased among peripheral blood mononuclear cells (PBMC) of infected mice. Further, CCL5/RANTES-driven in vitro PBMC migration was partially abrogated by the CCR1/CCR5 antagonist Met-RANTES. However, Met-RANTES treatment of infected mice altered neither parasitism nor intensity and nature of the CNS inflammation, indicating that T. cruzi-elicited meningoencephalitis is a CCR1/CCR5 independent process.Entities:
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Year: 2007 PMID： 17275101 DOI： 10.1016/j.jneuroim.2006.12.013
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478