| Literature DB >> 17274984 |
Cristiane Varella Lisboa1, Ana Paula Pinho, Rafael Veríssimo Monteiro, Ana Maria Jansen.
Abstract
The course of experimental infection of Swiss mice with 95 sylvatic Trypanosoma cruzi isolates included in TCI or TCII genotype was characterized. The purpose was to verify biological properties and its eventual correspondence with original host species, genotype or zymodeme. The isolates of T. cruzi were 100% infective, 55% resulted in patent parasitemia with 69% (36/52) of mortality. A meaningful biological heterogeneity was observed in both, TCI and TCII isolates. TCII isolates resulted in higher patent parasitemia 64% (38/59), in contrast to the 41% TCI infected Swiss mice (14/34). Parasitemia was not always associated to mortality. Higher biological heterogeneity was observed in T. cruzi II isolates derived from L. rosalia from the Atlantic Coastal Rain forest. TCII isolates derived from marsupials resulted in very similar infection profile in Swiss mice.Entities:
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Year: 2006 PMID： 17274984 DOI： 10.1016/j.exppara.2006.12.005
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011